Naslov
Porphyromonas gingivalis Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases

Autori
Horvat Aleksijević, Lorena ; Aleksijević, Marko ; Škrlec, Ivana ; Šram, Marko ; Šram, Miroslav ; Talapko, Jasminka

Izvornik
Pathogens (2076-0817) 11 (2022), 10; 1173, 20

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
atherosclerosis ; cardiology ; periodontitis ; Porphyromonas gingivalis ; virulence factors

Sažetak
Abstract: Porphyromonas gingivalis is a gram-negative, anaerobic bacterium that lives in the oral cav- ity. It is an integral part of the oral microbiome, which includes more than 500 types of bacteria. Under certain circumstances, as a consequence of virulence factors, it can become very destructive and proliferate to many cells in periodontal lesions. It is one of the causative agents present ex- tremely often in dental plaque and is the main etiological factor in the development of periodontal disease. During various therapeutic procedures, P. gingivalis can enter the blood and disseminate through it to distant organs. This primarily refers to the influence of periodontal agents on the de- velopment of subacute endocarditis and can facilitate the development of coronary heart disease, atherosclerosis, and ischemic infarction. The action of P. gingivalis is facilitated by numerous factors of virulence and pathogenicity such as fimbriae, hemolysin, hemagglutinin, capsules, outer mem- brane vesicles, lipopolysaccharides, and gingipains. A special problem is the possibility of biofilm formation. P. gingivalis in a biofilm is 500 to 1000 times less sensitive to antimicrobial drugs than planktonic cells, which represents a significant problem in the treatment of infections caused by this pathogen.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Dentalna medicina

POVEZANOST RADA