Naslov
Positive effect of consumption of functionally enriched food on microcirculation of healthy young subjects

Autori
Šušnjara, Petar ; Mihaljević, Zrinka ; Stupin, Ana ; Kolobarć , Nikolina ; Drenjančević, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Young Scientist's Conference

Mjesto i datum
Osijek, Hrvatska, 07.10.2022

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
functionally food, n-3 PUFA, vitamin E, selenium, lutein, microcirculation

Sažetak
Unbalanced and nutritionally poor diet leads to increased risk of endothelial dysfunction and other cardiovascular diseases, while optimal diet contributes to health and normal function of the endothelium. Aim of this study is to determine the effects of consumption of enriched hen eggs on microcirculation of healthy young subjects using Laser doppler flowmetry (LDF). Methods This was a randomized, double-blind, placebo-controlled interventional study (part of ID: NCT04564690, the study was registered on the clinicaltrial.gov). Subjects were divided in Control group (n=14 ; consumed regular hen eggs (1.785 mg of vitamin E, 0.330 mg of lutein, 0.054 mg of selenium and 438 mg of n-3 PUFAs daily), and Nutri4 group (n=20) who consumed enriched eggs (daily in total approximately 3.29 mg of vitamin E, 1.85 mg of lutein, 0.06 mg of selenium and 1026 mg of n-3 PUFAs), 3 eggs a day for 3 weeks. Before and after dietary protocols microvascular flow of the forearm skin (endothelium-dependent responses: post-occlusive reactive hyperemia (PORH) and iontophoresis of acetylcholine - AChID and sodium nitroprusside SNPID (endothelium-independent response endothelium)), protein expression of enzymes (COX1, COX2, iNOS, eNOS and nNOS), serum concentrations of n-3 PUFAs, vitamin E, selenium and lutein were measured. Results: PORH and AChID were significantly enhanced while SNPID remained unchanged, protein expression of COX2 was significantly higher in the NUTRI4 group while other analytes remained unchanged. Serum concentrations of n-3 PUFAs, vitamin E and lutein were significantly higher in the Nutri4 group while selenium remained unchanged compared to pre- diet values. Conclusion The consumption of enriched hen eggs have positive affects on microvascular reactivity, and this changes can be attributed to the positive effect of vasoactive COX2 metabolites and increased serum concentration of n-3 PUFAs, vitamin E and lutein.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA