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Pregled bibliografske jedinice broj: 1222086

The association of serotonin receptor genes polymorphisms with CSF, genetic, and neuropsychological biomarkers of Alzheimer's disease

Babić Leko, Mirjana; Nikolac Perković, Matea; Švob Štrac, Dubravka; Pleić, Nikolina; Gunjača, Ivana; Klepac, Nataša; Borovečki, Fran; Pivac, Nela; Zemunik, Tatijana; Hof, Patrick R.; Šimić, Goran
The association of serotonin receptor genes polymorphisms with CSF, genetic, and neuropsychological biomarkers of Alzheimer's disease // Neurologia Croatica 71 (Suppl. 3): 61 / Šimić, Goran ; Mimica, Ninoslav (ur.).
Zagreb: Denona, 2022. str. 61-61 (poster, domaća recenzija, sažetak, stručni)

CROSBI ID: 1222086 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The association of serotonin receptor genes polymorphisms with CSF, genetic, and neuropsychological biomarkers of Alzheimer's disease

Autori
Babić Leko, Mirjana ; Nikolac Perković, Matea ; Švob Štrac, Dubravka ; Pleić, Nikolina ; Gunjača, Ivana ; Klepac, Nataša ; Borovečki, Fran ; Pivac, Nela ; Zemunik, Tatijana ; Hof, Patrick R. ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Neurologia Croatica 71 (Suppl. 3): 61 / Šimić, Goran ; Mimica, Ninoslav - Zagreb : Denona, 2022, 61-61

Skup
Croatian congress on Alzheimer's disease (CROCAD-22)

Mjesto i datum
Supetar, Hrvatska, 05.10.2022. - 08.10.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Alzheimer's disease ; serotonin receptors ; biomarkers ; genetics ; cerebrospinal fluid

Sažetak
Serotonergic receptors are affected in Alzheimer's disease (AD). The overall decrease in the serotonergic transmission is also observed in AD. Previous studies showed the association of polymorphisms in genes for serotonin (5HT) receptors with behavioral and psychological symptoms of dementia (BPSD). In this study, we aimed to test if individuals carrying different genotypes in 5HTR2A rs 6313 (T102C), 5HTR1B rs13212041, 5HTR6 rs1805054 (C267T), and 5HTR2C rs 3813929 (-795C/T) polymorphisms have a higher risk for development of AD. Cerebrospinal fluid (CSF) AD biomarkers, neuropsychological tests, and apolipoprotein E (APOE) haplotype were determined in 115 AD patients and 53 mildly cognitively impaired patients, while 2701 cognitively healthy individuals with determined APOE haplotype were also included. We observed that all four analyzed polymorphisms in genes for 5HT receptors showed an association with either CSF, neuropsychological or genetic biomarkers of AD. Thus, the potential of these polymorphisms as early genetic biomarkers of AD should be further investigated.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Medicinski fakultet, Split

Profili:

Avatar Url Fran Borovečki (autor)

Avatar Url Nela Pivac (autor)

Avatar Url Nataša Klepac (autor)

Avatar Url Ivana Gunjača (autor)

Avatar Url Tatijana Zemunik (autor)

Avatar Url Goran Šimić (autor)

Avatar Url Nikolina Pleić (autor)

Avatar Url Dubravka Švob Štrac (autor)

Avatar Url Matea Nikolac Perković (autor)

Avatar Url Mirjana Babić Leko (autor)

Citiraj ovu publikaciju:

Babić Leko, Mirjana; Nikolac Perković, Matea; Švob Štrac, Dubravka; Pleić, Nikolina; Gunjača, Ivana; Klepac, Nataša; Borovečki, Fran; Pivac, Nela; Zemunik, Tatijana; Hof, Patrick R.; Šimić, Goran
The association of serotonin receptor genes polymorphisms with CSF, genetic, and neuropsychological biomarkers of Alzheimer's disease // Neurologia Croatica 71 (Suppl. 3): 61 / Šimić, Goran ; Mimica, Ninoslav (ur.).
Zagreb: Denona, 2022. str. 61-61 (poster, domaća recenzija, sažetak, stručni)
Babić Leko, M., Nikolac Perković, M., Švob Štrac, D., Pleić, N., Gunjača, I., Klepac, N., Borovečki, F., Pivac, N., Zemunik, T., Hof, P. & Šimić, G. (2022) The association of serotonin receptor genes polymorphisms with CSF, genetic, and neuropsychological biomarkers of Alzheimer's disease. U: Šimić, G. & Mimica, N. (ur.)Neurologia Croatica 71 (Suppl. 3): 61.
@article{article, author = {Babi\'{c} Leko, Mirjana and Nikolac Perkovi\'{c}, Matea and \v{S}vob \v{S}trac, Dubravka and Plei\'{c}, Nikolina and Gunja\v{c}a, Ivana and Klepac, Nata\v{s}a and Borove\v{c}ki, Fran and Pivac, Nela and Zemunik, Tatijana and Hof, Patrick R. and \v{S}imi\'{c}, Goran}, year = {2022}, pages = {61-61}, keywords = {Alzheimer's disease, serotonin receptors, biomarkers, genetics, cerebrospinal fluid}, title = {The association of serotonin receptor genes polymorphisms with CSF, genetic, and neuropsychological biomarkers of Alzheimer's disease}, keyword = {Alzheimer's disease, serotonin receptors, biomarkers, genetics, cerebrospinal fluid}, publisher = {Denona}, publisherplace = {Supetar, Hrvatska} }
@article{article, author = {Babi\'{c} Leko, Mirjana and Nikolac Perkovi\'{c}, Matea and \v{S}vob \v{S}trac, Dubravka and Plei\'{c}, Nikolina and Gunja\v{c}a, Ivana and Klepac, Nata\v{s}a and Borove\v{c}ki, Fran and Pivac, Nela and Zemunik, Tatijana and Hof, Patrick R. and \v{S}imi\'{c}, Goran}, year = {2022}, pages = {61-61}, keywords = {Alzheimer's disease, serotonin receptors, biomarkers, genetics, cerebrospinal fluid}, title = {The association of serotonin receptor genes polymorphisms with CSF, genetic, and neuropsychological biomarkers of Alzheimer's disease}, keyword = {Alzheimer's disease, serotonin receptors, biomarkers, genetics, cerebrospinal fluid}, publisher = {Denona}, publisherplace = {Supetar, Hrvatska} }

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