Naslov
Satellite DNAs in Health and Disease

Autori
Ugarković, Đurđica ; Sermek, Antonio ; Ljubić, Sven ; Feliciello, Isidoro

Izvornik
Genes (2073-4425) 13 (2022); 1154, 15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
satellite DNA ; heterochromatin ; satellite RNA ; epigenetics ; heat stress ; cancer ; biomarker

Sažetak
Tandemly repeated satellite DNAs are major components of centromeres and pericentromeric heterochromatin which are crucial chromosomal elements responsible for accurate chromosome segregation. Satellite DNAs also contribute to genome evolution and the speciation process and are important for the maintenance of the entire genome inside the nucleus. In addition, there is increasing evidence for active and tightly regulated transcription of satellite DNAs and role for their transcripts in diverse processes. In this review, we focus on recent discoveries related to the regulation of satellite DNA expression and the role of their transcripts either in heterochromatin establishment and centromere function or in gene expression regulation under various biological contexts. We discuss the role of satellite transcripts in the stress response and environmental adaptation as well as consequences of dysregulation of satellite DNA expression in cancer and their potential use as cancer biomarkers.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA