Naslov
Dietary exposure to organophosphate insecticides in Croatian adolescents - preliminary results of the Zagreb region Total Diet Study

Autori
Kovačić, Jelena ; Macan, Marija ; Garvey, Jim ; Jurič, Andreja ; Sulimanec Grgec, Antonija ; Sabolić, Ivana ; Macan, Jelena ; Murray, Brendan ; Varnai, Veda M.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / - , 2022, 247-248

Skup
14th European Pesticide Residues Workshop

Mjesto i datum
Bologna, Italija, 19.09.2022. - 23.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
dietary exposure ; pesticide residues ; foods and beverages

Sažetak
Study presents preliminary results on insufficiently explored dietary exposure to organophosphate insecticides (OP) in Croatian adolescents. Results were obtained in the Total Diet Study (TDS) in the region of Zagreb, under the framework of the PyrOPECh study (http://pyropech.imi.hr). Food samples, covering >=95% of the Croatian adolescents' diet, were prepared "as consumed", pooled and homogenised in a dedicated kitchen facility. Multiresidue analysis was performed at the Backweston Laboratory Complex of the Department of Agriculture, Food and the Marine, Celbridge, Ireland, using standard miniLuke extraction method and quantification by GC-High Resolution Accurate Mass Spectrometry and LC- triple quadrupole (Quality Control: SANTE/11312/2021). OP intake in Croatian population was estimated by Monte Carlo simulations using a food frequency questionnaire (FFQ) administered in 2008/2009 on 403 first-year college students (mean age: 18.8 years) who answered the questions regarding their diet during the pre-college year, and consumption data for the Croatian population from 2011. Additional assessment was performed by the EFSA DietEX v.1.0 and PRIMo v.3.1 tools, using our TDS measurements and consumption data for European adolescents. Out of 509 analysed composite samples (corresponding to 1800 sub-samples), residues of OP at levels above the limit of quantification, but below the maximum residue levels, were found in 5/195 vegetable samples (isocarbophos in four lettuce samples ; dimethoate and omethoate in one sample of spring onions), and in 1/145 samples of animal origin (coumaphos in honey). Monte Carlo simulations resulted in mean dietary exposure estimate for isocarbophos in Croatian subjects of 0.44 ng/kg bw/day, which agreed well with the estimates for the EU adolescent population (0.08 to 1.74 ng/kg bw/day). Exposure to coumaphos was higher in Croatia (0.26 ng/kg bw/day) compared to other EU adolescents (0.01 to 0.18 ng/kg bw/day). Due to the lack of suitable FFQ data, exposure to dimethoate and omethoate was estimated only for EU adolescents excluding Croatia (0.00007-0.006 and 0.0003-0.02 ng/kg bw/day for dimethoate and omethoate, respectively). Risk assessment (RA) for dimethoate and omethoate showed values well below the health reference values, whereas RA for other OPs was not performed due to the lack of health reference values. This research is funded by the Croatian Science Foundation (HrZZ IP-2019-04-7193) and collaborative efforts with the Department of Agriculture, Food and the Marine, Ireland.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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