Pregled bibliografske jedinice broj: 1219948
Salinomycin disturbs Golgi apparatus function and specifically affects cells in epithelial-to- mesenchymal transition
Salinomycin disturbs Golgi apparatus function and specifically affects cells in epithelial-to- mesenchymal transition, 2022. doi:10.1101/2022.08.31.506024 (rukopis).
CROSBI ID: 1219948 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Salinomycin disturbs Golgi apparatus function and
specifically affects cells in epithelial-to-
mesenchymal transition
Autori
Marjanović, Marko ; Dražić, Ana-Matea Mikecin ; Mioč, Marija ; Kliček, Filip ; Novokmet, Mislav ; Lauc, Gordan ; Kralj, Marijeta
Izvornik
BioRxiv
Vrsta, podvrsta
Ostale vrste radova, rukopis
Godina
2022
Ključne riječi
EMT, breast CSCs, Golgi apparatus, ER, salinomycin, monensin, N-glycosylation
Sažetak
Epithelial-to-mesenchymal transition (EMT) gives rise to cells with properties similar to cancer stem cells (CSCs). Targeting the EMT program to selectively eliminate CSCs is a promising way to improve cancer therapy. Salinomycin (Sal), a K+/H+ ionophore, was identified as highly selective towards CSC-like cells, but its mechanism of action and selectivity remains elusive. Here we show that Sal, similarly to monensin and nigericin, disturbs the function of the Golgi apparatus (GA). Sal alters the expression of GA- related genes and leads to marked changes in GA morphology, particularly in cells that underwent EMT. Moreover, GA disturbing agents severely affect protein post-translational modifications including protein processing, glycosylation and secretion. We discover that the alterations induced by GA disturbing agents specifically affect the viability of EMT cells. Collectively, our work identifies a new vulnerability related to the EMT, suggesting that targeting the GA is a novel therapeutic approach against CSCs.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti, Farmacija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Projekti:
IP-2013-11-5660 - Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija (MultiCaST) (Kralj, Marijeta, HRZZ - 2013-11) ( CroRIS)
EK-EFRR-KK.01.2.1.01.0003 - Nova generacija visokoprotočnih glikoservisa (Lauc, Gordan; Gornik Kljaić, Olga; Zoldoš, Vlatka, EK - Poziv na dostavu projektnih prijedloga „Povećanje razvoja novih proizvoda i usluga koji proizlaze iz aktivnosti istraživanja i razvoja“) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
GENOS d.o.o.
Profili:
Marko Marjanović
(autor)
Gordan Lauc
(autor)
Filip Kliček
(autor)
Marijeta Kralj
(autor)
Mislav Novokmet
(autor)
Marija Mioč
(autor)
Ana-Matea Mikecin Dražić
(autor)