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Pregled bibliografske jedinice broj: 1219948

Salinomycin disturbs Golgi apparatus function and specifically affects cells in epithelial-to- mesenchymal transition


Marjanović, Marko; Dražić, Ana-Matea Mikecin; Mioč, Marija; Kliček, Filip; Novokmet, Mislav; Lauc, Gordan; Kralj, Marijeta
Salinomycin disturbs Golgi apparatus function and specifically affects cells in epithelial-to- mesenchymal transition, 2022. doi:10.1101/2022.08.31.506024 (rukopis).


CROSBI ID: 1219948 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Salinomycin disturbs Golgi apparatus function and specifically affects cells in epithelial-to- mesenchymal transition

Autori
Marjanović, Marko ; Dražić, Ana-Matea Mikecin ; Mioč, Marija ; Kliček, Filip ; Novokmet, Mislav ; Lauc, Gordan ; Kralj, Marijeta

Izvornik
BioRxiv

Vrsta, podvrsta
Ostale vrste radova, rukopis

Godina
2022

Ključne riječi
EMT, breast CSCs, Golgi apparatus, ER, salinomycin, monensin, N-glycosylation

Sažetak
Epithelial-to-mesenchymal transition (EMT) gives rise to cells with properties similar to cancer stem cells (CSCs). Targeting the EMT program to selectively eliminate CSCs is a promising way to improve cancer therapy. Salinomycin (Sal), a K+/H+ ionophore, was identified as highly selective towards CSC-like cells, but its mechanism of action and selectivity remains elusive. Here we show that Sal, similarly to monensin and nigericin, disturbs the function of the Golgi apparatus (GA). Sal alters the expression of GA- related genes and leads to marked changes in GA morphology, particularly in cells that underwent EMT. Moreover, GA disturbing agents severely affect protein post-translational modifications including protein processing, glycosylation and secretion. We discover that the alterations induced by GA disturbing agents specifically affect the viability of EMT cells. Collectively, our work identifies a new vulnerability related to the EMT, suggesting that targeting the GA is a novel therapeutic approach against CSCs.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti, Farmacija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
IP-2013-11-5660 - Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija (MultiCaST) (Kralj, Marijeta, HRZZ - 2013-11) ( CroRIS)
EK-EFRR-KK.01.2.1.01.0003 - Nova generacija visokoprotočnih glikoservisa (Lauc, Gordan; Gornik Kljaić, Olga; Zoldoš, Vlatka, EK - Poziv na dostavu projektnih prijedloga „Povećanje razvoja novih proizvoda i usluga koji proizlaze iz aktivnosti istraživanja i razvoja“) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
GENOS d.o.o.

Poveznice na cjeloviti tekst rada:

doi www.biorxiv.org

Citiraj ovu publikaciju:

Marjanović, Marko; Dražić, Ana-Matea Mikecin; Mioč, Marija; Kliček, Filip; Novokmet, Mislav; Lauc, Gordan; Kralj, Marijeta
Salinomycin disturbs Golgi apparatus function and specifically affects cells in epithelial-to- mesenchymal transition, 2022. doi:10.1101/2022.08.31.506024 (rukopis).
Marjanović, M., Dražić, A., Mioč, M., Kliček, F., Novokmet, M., Lauc, G. & Kralj, M. (2022) Salinomycin disturbs Golgi apparatus function and specifically affects cells in epithelial-to- mesenchymal transition. BioRxiv. Rukopis doi:10.1101/2022.08.31.506024.
@unknown{unknown, author = {Marjanovi\'{c}, Marko and Dra\v{z}i\'{c}, Ana-Matea Mikecin and Mio\v{c}, Marija and Kli\v{c}ek, Filip and Novokmet, Mislav and Lauc, Gordan and Kralj, Marijeta}, year = {2022}, DOI = {10.1101/2022.08.31.506024}, keywords = {EMT, breast CSCs, Golgi apparatus, ER, salinomycin, monensin, N-glycosylation}, doi = {10.1101/2022.08.31.506024}, title = {Salinomycin disturbs Golgi apparatus function and specifically affects cells in epithelial-to- mesenchymal transition}, keyword = {EMT, breast CSCs, Golgi apparatus, ER, salinomycin, monensin, N-glycosylation} }
@unknown{unknown, author = {Marjanovi\'{c}, Marko and Dra\v{z}i\'{c}, Ana-Matea Mikecin and Mio\v{c}, Marija and Kli\v{c}ek, Filip and Novokmet, Mislav and Lauc, Gordan and Kralj, Marijeta}, year = {2022}, DOI = {10.1101/2022.08.31.506024}, keywords = {EMT, breast CSCs, Golgi apparatus, ER, salinomycin, monensin, N-glycosylation}, doi = {10.1101/2022.08.31.506024}, title = {Salinomycin disturbs Golgi apparatus function and specifically affects cells in epithelial-to- mesenchymal transition}, keyword = {EMT, breast CSCs, Golgi apparatus, ER, salinomycin, monensin, N-glycosylation} }

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