Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1219939

MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGULATION OF PROTEIN GLYCOSYLATION IN LIVER AND PANCREATIC CELL MODELS

Vičić Bočkor, Vedrana; Klasić, Marija; Josipović, Goran; Vujić, Ana; Foglar, Nika; Smajlović, Samira; Keser, Toma; Lauc, Gordan; Vojta, Aleksandar; Zoldoš, Vlatka
MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGULATION OF PROTEIN GLYCOSYLATION IN LIVER AND PANCREATIC CELL MODELS // Journal of Bioanthropology
Zagreb: Institut za antropologiju, 2022. str. 153-153 doi:10.54062/jb (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 1219939 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGULATION OF PROTEIN GLYCOSYLATION IN LIVER AND PANCREATIC CELL MODELS
(MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGU)

Autori
Vičić Bočkor, Vedrana ; Klasić, Marija ; Josipović, Goran ; Vujić, Ana ; Foglar, Nika ; Smajlović, Samira ; Keser, Toma ; Lauc, Gordan ; Vojta, Aleksandar ; Zoldoš, Vlatka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Bioanthropology / - Zagreb : Institut za antropologiju, 2022, 153-153

Skup
12th ISABS Conference on Forensic and Anthropologic Genetics and Mayo Clinic Lectures in Individidualized Medicine

Mjesto i datum
Dubrovnik, Hrvatska, 22.07.2022. - 27.07.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
epigenetics, CRISPR/dCas9, glycogenes, protein glycosylation

Sažetak
Transcription factors HNF1A, HNF4A and FOXA1/2/3 regulate developmental and tissue-specific transcriptional gene networks in liver and pancreas.Alternative glycosylation affects protein structure and function, and aberrant protein glycosylation is observed in inflammation, diabetes and cancer.For instance, abnormal glucose stimulated insulin secretion in diabetes might occur through epigenetic changes in HNF1A and FOXA2, resulting in deregulation of MGAT4A, MGAT4B and MGAT5 glycosyltransferases responsible for proper glycosylaton of GLUT receptors on beta cells. In addition, HNF1A is identified by GWAS studies as a master regulator of key fucosyltransferases in liver.Following CRISPR-based manipulations, we analysed total protein glycosylation.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Vlatka Zoldoš (autor)

Avatar Url Gordan Lauc (autor)

Avatar Url Toma Keser (autor)

Avatar Url Goran Josipović (autor)

Avatar Url Vedrana Vičić Bočkor (autor)

Avatar Url Nika Foglar (autor)

Avatar Url Ana Vujić (autor)

Avatar Url Marija Klasić (autor)

Avatar Url Aleksandar Vojta (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Vičić Bočkor, Vedrana; Klasić, Marija; Josipović, Goran; Vujić, Ana; Foglar, Nika; Smajlović, Samira; Keser, Toma; Lauc, Gordan; Vojta, Aleksandar; Zoldoš, Vlatka
MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGULATION OF PROTEIN GLYCOSYLATION IN LIVER AND PANCREATIC CELL MODELS // Journal of Bioanthropology
Zagreb: Institut za antropologiju, 2022. str. 153-153 doi:10.54062/jb (poster, međunarodna recenzija, sažetak, znanstveni)
Vičić Bočkor, V., Klasić, M., Josipović, G., Vujić, A., Foglar, N., Smajlović, S., Keser, T., Lauc, G., Vojta, A. & Zoldoš, V. (2022) MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGULATION OF PROTEIN GLYCOSYLATION IN LIVER AND PANCREATIC CELL MODELS. U: Journal of Bioanthropology doi:10.54062/jb.
@article{article, author = {Vi\v{c}i\'{c} Bo\v{c}kor, Vedrana and Klasi\'{c}, Marija and Josipovi\'{c}, Goran and Vuji\'{c}, Ana and Foglar, Nika and Smajlovi\'{c}, Samira and Keser, Toma and Lauc, Gordan and Vojta, Aleksandar and Zoldo\v{s}, Vlatka}, year = {2022}, pages = {153-153}, DOI = {10.54062/jb}, keywords = {epigenetics, CRISPR/dCas9, glycogenes, protein glycosylation}, doi = {10.54062/jb}, title = {MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGULATION OF PROTEIN GLYCOSYLATION IN LIVER AND PANCREATIC CELL MODELS}, keyword = {epigenetics, CRISPR/dCas9, glycogenes, protein glycosylation}, publisher = {Institut za antropologiju}, publisherplace = {Dubrovnik, Hrvatska} }
@article{article, author = {Vi\v{c}i\'{c} Bo\v{c}kor, Vedrana and Klasi\'{c}, Marija and Josipovi\'{c}, Goran and Vuji\'{c}, Ana and Foglar, Nika and Smajlovi\'{c}, Samira and Keser, Toma and Lauc, Gordan and Vojta, Aleksandar and Zoldo\v{s}, Vlatka}, year = {2022}, pages = {153-153}, DOI = {10.54062/jb}, keywords = {epigenetics, CRISPR/dCas9, glycogenes, protein glycosylation}, doi = {10.54062/jb}, title = {MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGU}, keyword = {epigenetics, CRISPR/dCas9, glycogenes, protein glycosylation}, publisher = {Institut za antropologiju}, publisherplace = {Dubrovnik, Hrvatska} }

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.