Naslov
The role of immune mechanisms in development of metabolic syndrome in obesity

Autori
Marinović, Sonja

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, doktorska disertacija

Fakultet
Prirodoslovno-matematicki fakultet

Mjesto
Zagreb

Datum
12.07

Godina
2018

Stranica
111

Mentor
Bojan Polić ; Danka Grčević

Ključne riječi
diabetes mellitus type 2 ; γδ T cells ; IL-17A ; non-alcoholic fatty liver disease ; NKG2D receptor ; stress induced molecules

Sažetak
More than billion of obese and overweight people live currently in the world. A significant number of them develop diabetes mellitus type 2 (DM2) and non-alcoholic fatty liver disease (NAFLD). Mechanisms that induce inflammation and trigger transition from prediabetes to DM2 or from hepatic steatosis to non-alcoholic steatohepatitis (NASH) are still unclear. In this research I found that γδ T cells are enriched in visceral adipose tissue and they produce proinflammatory cytokines. In response to high fat diet (HFD), there is increase in number of γδ T cells that produce IL-17A. Research on NAFLD revealed that initiating event, in response to high calorie diet, is the increase in expression of the NKG2D ligand H60 on hepatocytes. Upregulation of ligands leads to mobilisation of γδ T cells through an NKG2D engagement that induces an increase in IL-17A. Lack of either γδ T cells, NKG2D or IL-17A significantly decreases development of liver fibrosis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti

POVEZANOST RADA