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Pregled bibliografske jedinice broj: 1218729

Application of PAT for Advanced Crystallization Process Control


Bolf, Nenad; Šahnić, Damir; Gavran, Matea; Sacher, Josip; Herceg, Srečko
Application of PAT for Advanced Crystallization Process Control // 17th Process Analytics Colloquium (PAT), Book of Abstract / Dahlmann, Katharina (ur.).
Amersfoort: Deutsche Gesellschaft für chemisches Apparatewesen (DECHEMA), 2022. P04, 2 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1218729 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Application of PAT for Advanced Crystallization Process Control

Autori
Bolf, Nenad ; Šahnić, Damir ; Gavran, Matea ; Sacher, Josip ; Herceg, Srečko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
17th Process Analytics Colloquium (PAT), Book of Abstract / Dahlmann, Katharina - Amersfoort : Deutsche Gesellschaft für chemisches Apparatewesen (DECHEMA), 2022

Skup
17th Process Analytics Colloquium (PAT)

Mjesto i datum
Amersfoort, Nizozemska, 19.09.2022. - 21.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
process analytical technology, real-time process control, crystallization,

Sažetak
Owning to the technological advancements in the recent decades, methods and systems relying on fast measurement provided by various PAT are extensively being developed with the purpose of monitoring and control of key process variables in real-time and are an integral part of the Quality by Design (QbD) and Quality by Control (QbC) concepts. The application of these concepts have proven to be beneficial both during the development stage and in the production stage of the API lifecycle in a way that they enable better process understanding, increased process robustness and full control over the Critical Process Parameters (CPP’s) and Critical Quality Attributes (CQA’s). The purpose of this research is to develop a system based on HDR microscopy, ATR-FTIR and Raman spectroscopy in combination with multivariate analytical methods that will enable continuous monitoring and control of crystallization processes. Furthermore, it will aid in finding the optimal crystallization conditions to obtain products of desired CQA’s. HDR microscopy and Raman spectroscopy are incorporated in a single probe used for measurements of chord length distributions, solute concentrations, solid loadings and the detection of polymorphic forms. FTIR is also employed via a separate probe to optionally monitor solute concentrations in real time. The goal is to develop a model free process control system where all of the CPP’s and CQA’s of a given crystallization process can be monitored and controlled in real time with little or no negative impact on the hydrodynamics of the system which is a common issue when multiple PAT tools are applied in monitoring processes at lab scale. The laboratory crystallization setup is comprised of a glass jacketed batch reactor connected to a thermostat unit and equipped with PAT tools. An in-house software platform was developed that enables real time collection of FTIR and Raman spectra together with the corresponding process temperature data. The platform is used to gather data for calibration model development and later on for process monitoring and control. It has proved to be stable and is capable of providing high quality linear and non-linear models used for monitoring and control.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kemijsko inženjerstvo



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.1.1.07.0017 - Napredno vođenje procesa kristalizacije (CrystAPC) (Bolf, Nenad, EK - KK.01.1.1.07) ( CroRIS)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
PLIVA HRVATSKA d.o.o.

Profili:

Avatar Url Srečko Herceg (autor)

Avatar Url Nenad Bolf (autor)

Avatar Url Matea Gavran (autor)

Avatar Url Damir Šahnić (autor)

Avatar Url Josip Sacher (autor)


Citiraj ovu publikaciju:

Bolf, Nenad; Šahnić, Damir; Gavran, Matea; Sacher, Josip; Herceg, Srečko
Application of PAT for Advanced Crystallization Process Control // 17th Process Analytics Colloquium (PAT), Book of Abstract / Dahlmann, Katharina (ur.).
Amersfoort: Deutsche Gesellschaft für chemisches Apparatewesen (DECHEMA), 2022. P04, 2 (poster, međunarodna recenzija, sažetak, znanstveni)
Bolf, N., Šahnić, D., Gavran, M., Sacher, J. & Herceg, S. (2022) Application of PAT for Advanced Crystallization Process Control. U: Dahlmann, K. (ur.)17th Process Analytics Colloquium (PAT), Book of Abstract.
@article{article, author = {Bolf, Nenad and \v{S}ahni\'{c}, Damir and Gavran, Matea and Sacher, Josip and Herceg, Sre\v{c}ko}, editor = {Dahlmann, K.}, year = {2022}, pages = {2}, chapter = {P04}, keywords = {process analytical technology, real-time process control, crystallization,}, title = {Application of PAT for Advanced Crystallization Process Control}, keyword = {process analytical technology, real-time process control, crystallization,}, publisher = {Deutsche Gesellschaft f\"{u}r chemisches Apparatewesen (DECHEMA)}, publisherplace = {Amersfoort, Nizozemska}, chapternumber = {P04} }
@article{article, author = {Bolf, Nenad and \v{S}ahni\'{c}, Damir and Gavran, Matea and Sacher, Josip and Herceg, Sre\v{c}ko}, editor = {Dahlmann, K.}, year = {2022}, pages = {2}, chapter = {P04}, keywords = {process analytical technology, real-time process control, crystallization,}, title = {Application of PAT for Advanced Crystallization Process Control}, keyword = {process analytical technology, real-time process control, crystallization,}, publisher = {Deutsche Gesellschaft f\"{u}r chemisches Apparatewesen (DECHEMA)}, publisherplace = {Amersfoort, Nizozemska}, chapternumber = {P04} }




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