Naslov
Influence of side-chain length on antifungal efficacy of N-alkyl nicotinamide-based compounds

Autori
Tot, Aleksanda ; Vrandečić, Karolina ; Ćosić, Jasenka ; Matić, Magdalena ; Vraneš, Milan

Izvornik
Environmental science and pollution research (0944-1344) 29 (2022); 71742-71751

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Nicotinamide, Toxicity, Fusarium graminearum, Sclerotinia sclerotiorum, Botrytis cinerea, DFT calculations, Sclerotinia sclerotiorum, Botrytis cinerea, DFT calculations

Sažetak
This article presents fungicidal properties of 9 synthesized nicotinamide-bromides with different alkyl side chain lengths toward Fusarium graminearum, Sclerotinia sclerotiorum, and Botrytis cinerea which were examined. The fungicidal properties were determined by the measurement of the radial growth of fungi, followed by the calculation of the antifungal index. The obtained results were correlated with the descriptors from DFT calculations to determine structural features that affect the fungicidal properties of nicotinamides. Based on the experimental and theoretical results, it was confirmed that F. graminearum is most resistant to the change of lipophilicity of compounds, while S. sclerotiorum is most sensitive. For all investigated compounds, the growth rate decreased with the increase of carbon atoms in the side chain until tetradecylnicotinamidium bromide, [C14Nic][Br], while the further prolongation of the alkyl side chain increased the growth rate of fungus. This behavior was explained by the distinguished hydrophobic and hydrophilic surfaces in [C14Nic][Br] due to interactions between keto oxygen and bromide anion absent in the case of nicotinamides with a longer chain.

Izvorni jezik
Engleski

Znanstvena područja
Poljoprivreda (agronomija)

POVEZANOST RADA