Naslov
Interrelationship of monocyte chemoattractant protein-1 and parameters of diastolic dysfunction in patients with psoriatic arthritis

Autori
Uravić Bursać, Iva ; Drvar, Vedrana ; Kehler, Tatjana ; Peršić, Viktor ; Laškarin, Gordana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Program and Abstract book / - , 2022, 133-133

Skup
3rd Regional Congress of Physiological Societies and 5th Congress of Croatian physiological Society

Mjesto i datum
NP Plitvička jezera, Hrvatska, 22.09.2022. - 24.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
diastolic dysfunction ; echocardiography ; heart failure ; monocyte chemoattractant protein-1 ; psoriatic arthritis ; spondyloarthritis

Sažetak
Introduction: During active disease in psoriatic skin lesions and synovial tissue, activated monocytes represent the major source of proinflammatory mediators, including the chemokine MCP-1 [Furst 2019.]. Patients with PsA show multiple cardiovascular diseases, including heart failure [Jamil 2021.]. Aim:. We aimed to evaluate diagnostic accuracy of the proinflammatory monocyte chemotactic protein-1 (MCP-1) in the diagnosis of asymptomatic diastolic dysfunction (DD) in patients with psoriatic arthritis (PsA). Patients and methods: Sixty-three patients with axial and peripheral PsA without clinical manifestations of heart failure or NYHA (New York Heart Association) class 0 [McDonagh 2021], who were treated in rheumatologic office in “Thalassotherapia - Opatija”, Opatija, Croatia were recruited in this study, and sign Informed Consent. Cardiac ultrasound was done according to the current recommendations of the American Society of Echocardiography and the European Association of Cardiovascular Imaging [Lang 2015., Nagueh 2016.]. ELISA metod was used for measure MCP-1 concentration. Results: The serum MCP-1 concentration in patients with PsA did not correlate with the E-wave, whereas it showed a significant positive correlation with the A-wave (P = 0.00001, ). The MCP-1 concentration was negatively correlated with the E/A ratio (P = 0.00004). However, it did not show a correlation with the LAVI or TR values. The MCP-1 concentration showed a significant negative correlation with the TDI parameters E' wave (P = 0.0023), whereas the correlation between the MCP-1 concentration and the E/E’ ratio was positive (P = 0.00038). The MCP-1 concentration showed a significant negative correlation with the SA value (P = 0.01) and the SrA waves (P = 0.04), whereas it was not correlated with the SrE wave. MCP-1 concentrations did not correlate with the systolic function parameters EF and GLS. Conclusion: MCP-1 can serve as a non-invasive, independent prognostic parameter to diagnose isolated asymptomatic DD in patients with PsA and preserved left ventricular EF ≥ 50, as confirmed by echocardiography.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA