Naslov
Supression of tumour cells growth exposed to novel vanadium complexes

Autori
Filipović, Nikolina ; Šarić, Stjepan ; Marković, Berislav ; Mišković Špoljarić, Katarina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
19. Ružička days - Today science - tomorrow industry / - , 2022, 115-115

Skup
19. Ružičkini dani "Danas znanost - sutra industrija"

Mjesto i datum
Vukovar, Hrvatska, 21.09.2022. - 23.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
vanadium complexes, MTT assay, cells growth

Sažetak
In the last 15 years’ significant progress has been accomplished in synthesis of new metal compounds with emphasis to transition metal. The focus of our research are new complexes of vanadium and their antiproliferative abilities on cancer cell lines. The vanadium compounds were synthesized from V2O5 (V1 group of compounds) and VOSO4 x H2O (V2 group of compounds), and ligands from the hydroxypyrone group: chromone-2- carboxylic acid and cumalic acid. After synthesis by classical solution chemistry in stoichiometric ratio (1:1, metal: ligand), the compounds were dissolved in water (10-3 mol / dm3) and subjected to MTT assay (cytotoxicity test). In addition to the compounds, the activity of the ligands was also tested. The assay was performed on 6 cancer cell lines (Caco-2, HT-29, Hep-G2, KATO III, NCI-H 358, MDA-MB 231) and one normal human cell line (MRC-5). The results show that both groups of vanadium compounds demonstrate exceptional cytotoxicity against human cancer cells (MDA-MB 231): the cell survival at the highest concentrations (10-5 mol/dm3) is 29%. The antiproliferative effect was also observed on the following cell lines: KATO III (V1: 58.2%, V2: 51.3%), Hep-G2 (V1: 66.9%, V2: 59.4%), NCI-H358 (V1: 58.1%, V2: 58.4%). The inhibitory effect on the HT-29 and Caco-2 cell lines is less than 25%. Unlike the compounds, the ligands did not show antiproliferative activity on any cell line and the survival was > 95%. Based on such results, it can be concluded that the newly synthesized groups of vanadium compounds have the potential for future researches on antiproliferative activity on various cancer cell lines with emphasis to breast cancer (MDA-MB 231).

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA