Naslov
Potential antitumor activity of copper(II) complex with chromone-2-carboxylic acid

Autori
Jakić, Marija ; Šarić, Stjepan ; Filipović, Nikolina ; Marković, Berislav ; Mišković Špoljarić, Katarina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ISC Green 2022 / - Osijek, 2022, 93-93

Skup
2. međunarodna studentska GREEN konferencija = 2nd International Students’ GREEN Conference (ISC GREEN 2022)

Mjesto i datum
Osijek, Hrvatska, 02.06.2022. - 03.06.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
copper(II) complex, MTT assay, antitumor activity

Sažetak
Copper is one of the essential metals in biological systems and decades ago "in vitro" research showed that copper plays an important role in angioneogenesis. With this realization, research on copper complexes with chelated ligands began. Elevated copper concentrations have been observed in many human cancers. Copper toxicity is caused by its ability to produce reactive oxygen species (ROS), replace binding sites with other metal ions, peroxidize lipids, and directly cleave DNA and RNA. The copper (II) complex with chromone-2-carboxylic acid was synthesized using classical solution chemistry method, and its antitumor activity was investigated by MTT assay on 7 cell lines. The malignant cell lines were: Caco-2, HT -29 MDA-MB 231, KATO III, Hep-G2, NCI-H358. The normal cell line was MRC-5. The studied copper (II) complex suppressed cell growth of Hep-G2 cells at the highest concentration (10-5 M) by 64.8%, followed by NCI-H358, MRC-5 and HT -29 (45.6% ; 45.3% ; 43.4%). The inhibitory effect of copper (II) complex on KATO III, MDA-MB 231 and Caco-2 is less than 25%, indicating a low proliferation inhibitory effect. The results presented here indicate that the novel copper (II) complex may represent a promising structural starting point for the development of a new generation of potential antitumor agents.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA