Naslov
STUDIJ ADAMANTILTRIPEPTIDA UGRAĐENIH U LIPOSOME ESR METODOM
(ADAMANTYLTRIPEPTIDES ENTRAPPED INTO LIPOSOMES STUDIED BY SPIN LABELLING OF LIPOSOMES)

Autori
Nöthig-Laslo, Vesna ; Frkanec, Ruža ; Vranešić, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XVIII.hrvatski skup kemičara i kemijskih inženjera - sažetci (abstracts) / Zrnčević, Stanka - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo, 2003

Skup
XVIII.hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Zagreb, Hrvatska, 16.02.2003. - 19.02.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
adamantyltripeptides; liposomes; ESR
(adamantiltripeptidi; liposomi; ESR)

Sažetak
The peptides of particular interest for pharmaceutical applications are those which exhibit immunological activity. Compounds comprising the elements of bacterical peptidoglycan structure have been recognized as an important group of immunomodulators. Synthetic adamantyltripeptides, D- and L-(adamant-2-yl)-Gly-L-Ala-D-isoGln (AdTP1 and AdTP2) comprise adamantyl moiety linked to dipeptide L-Ala-D-isoGln which is a structural element of natural peptidoglycans, were shown to exhibit versatile biological activity [1, 2]. We have been examinig their encapsulation into liposomes with the aim to increase and optimize their therapeutic effect. Adamantyltripeptides were studied entrapped into large multilamelar liposomes. In order to show how the examined peptides incorporated into liposomes affect membrane properties, electron spin resonance, a spin labelling method was used. The multilamelar liposomes were spin labelled with n-doxyl stearic acid (n=5, 7, 12, 16) and dynamic properties of the nitroxide label were studied as a function of the entrapped adamantyltripeptides. [1] Vranešić, B., Tomašić, J., Smerdel, S., Kantoci, D., Benedetti, F., Helv. Chim. Acta 76 (1993) 1752. [2] Tomašić, J., Hanzl-Dujmović, I., Špoljar, B., Vranešić, B., Šantak, M., Jovičić, A., Vaccine 8 (2000) 1236.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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