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Current Concepts of Vitiligo Immunopathogenesis


Hlača, Nika; Žagar, Tina; Kaštelan, Marija; Brajac, Ines; Prpić-Massari, Larisa
Current Concepts of Vitiligo Immunopathogenesis // Biomedicines, 10 (2022), 7; no. 7: 1639, 18 doi:10.3390/biomedicines10071639 (međunarodna recenzija, članak, znanstveni)


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Naslov
Current Concepts of Vitiligo Immunopathogenesis

Autori
Hlača, Nika ; Žagar, Tina ; Kaštelan, Marija ; Brajac, Ines ; Prpić-Massari, Larisa

Izvornik
Biomedicines (2227-9059) 10 (2022), 7; No. 7: 1639, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
autoimmune diseases ; dendritic cells ; keratinocytes ; melanocytes ; memory T cells ; natural killer cells ; oxidative stress ; Th1 cells ; vitiligo

Sažetak
Vitiligo is an acquired immune-mediated disorder of pigmentation clinically characterized by well- defined depigmented or chalk-white macules and patches on the skin. The prevalence of vitiligo varies by geographical area, affecting 0.5% to 2% of the population. The disease imposes a significant psychological burden due to its major impact on patients’ social and emotional aspects of life. Given its autoimmune background, vitiligo is frequently associated with other autoimmune diseases or immune-mediated diseases. Vitiligo is a multifaceted disorder that involves both genetic predisposition and environmental triggers. In recent years, major predisposing genetic loci for the development of vitiligo have been discovered. The current findings emphasize the critical role of immune cells and their mediators in the immunopathogenesis of vitiligo. Oxidative-stress- mediated activation of innate immunity cells such as dendritic cells, natural killer, and ILC-1 cells is thought to be a key event in the early onset of vitiligo. Innate immunity cells serve as a bridge to adaptive immunity cells including T helper 1 cells, cytotoxic T cells and resident memory T cells. IFN-γ is the primary cytokine mediator that activates the JAK/STAT pathway, causing keratinocytes to produce the key chemokines CXCL9 and CXCL10. Complex interactions between immune and non-immune cells finally result in apoptosis of melanocytes. This paper summarizes current knowledge on the etiological and genetic factors that contribute to vitiligo, with a focus on immunopathogenesis and the key cellular and cytokine players in the disease’s inflammatory pathways.

Izvorni jezik
Engleski



POVEZANOST RADA


Profili:

Avatar Url Larisa Prpić Massari (autor)

Avatar Url Ines Brajac (autor)

Avatar Url Marija Kaštelan (autor)

Avatar Url Nika Hlača (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Hlača, Nika; Žagar, Tina; Kaštelan, Marija; Brajac, Ines; Prpić-Massari, Larisa
Current Concepts of Vitiligo Immunopathogenesis // Biomedicines, 10 (2022), 7; no. 7: 1639, 18 doi:10.3390/biomedicines10071639 (međunarodna recenzija, članak, znanstveni)
Hlača, N., Žagar, T., Kaštelan, M., Brajac, I. & Prpić-Massari, L. (2022) Current Concepts of Vitiligo Immunopathogenesis. Biomedicines, 10 (7), no. 7: 1639, 18 doi:10.3390/biomedicines10071639.
@article{article, author = {Hla\v{c}a, Nika and \v{Z}agar, Tina and Ka\v{s}telan, Marija and Brajac, Ines and Prpi\'{c}-Massari, Larisa}, year = {2022}, pages = {18}, DOI = {10.3390/biomedicines10071639}, chapter = {no. 7: 1639}, keywords = {autoimmune diseases, dendritic cells, keratinocytes, melanocytes, memory T cells, natural killer cells, oxidative stress, Th1 cells, vitiligo}, journal = {Biomedicines}, doi = {10.3390/biomedicines10071639}, volume = {10}, number = {7}, issn = {2227-9059}, title = {Current Concepts of Vitiligo Immunopathogenesis}, keyword = {autoimmune diseases, dendritic cells, keratinocytes, melanocytes, memory T cells, natural killer cells, oxidative stress, Th1 cells, vitiligo}, chapternumber = {no. 7: 1639} }
@article{article, author = {Hla\v{c}a, Nika and \v{Z}agar, Tina and Ka\v{s}telan, Marija and Brajac, Ines and Prpi\'{c}-Massari, Larisa}, year = {2022}, pages = {18}, DOI = {10.3390/biomedicines10071639}, chapter = {no. 7: 1639}, keywords = {autoimmune diseases, dendritic cells, keratinocytes, melanocytes, memory T cells, natural killer cells, oxidative stress, Th1 cells, vitiligo}, journal = {Biomedicines}, doi = {10.3390/biomedicines10071639}, volume = {10}, number = {7}, issn = {2227-9059}, title = {Current Concepts of Vitiligo Immunopathogenesis}, keyword = {autoimmune diseases, dendritic cells, keratinocytes, melanocytes, memory T cells, natural killer cells, oxidative stress, Th1 cells, vitiligo}, chapternumber = {no. 7: 1639} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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