Pregled bibliografske jedinice broj: 1214852
Current Concepts of Vitiligo Immunopathogenesis
Current Concepts of Vitiligo Immunopathogenesis // Biomedicines, 10 (2022), 7; no. 7: 1639, 18 doi:10.3390/biomedicines10071639 (međunarodna recenzija, članak, znanstveni)
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Naslov
Current Concepts of Vitiligo Immunopathogenesis
Autori
Hlača, Nika ; Žagar, Tina ; Kaštelan, Marija ; Brajac, Ines ; Prpić-Massari, Larisa
Izvornik
Biomedicines (2227-9059) 10
(2022), 7;
No. 7: 1639, 18
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
autoimmune diseases ; dendritic cells ; keratinocytes ; melanocytes ; memory T cells ; natural killer cells ; oxidative stress ; Th1 cells ; vitiligo
Sažetak
Vitiligo is an acquired immune-mediated disorder of pigmentation clinically characterized by well- defined depigmented or chalk-white macules and patches on the skin. The prevalence of vitiligo varies by geographical area, affecting 0.5% to 2% of the population. The disease imposes a significant psychological burden due to its major impact on patients’ social and emotional aspects of life. Given its autoimmune background, vitiligo is frequently associated with other autoimmune diseases or immune-mediated diseases. Vitiligo is a multifaceted disorder that involves both genetic predisposition and environmental triggers. In recent years, major predisposing genetic loci for the development of vitiligo have been discovered. The current findings emphasize the critical role of immune cells and their mediators in the immunopathogenesis of vitiligo. Oxidative-stress- mediated activation of innate immunity cells such as dendritic cells, natural killer, and ILC-1 cells is thought to be a key event in the early onset of vitiligo. Innate immunity cells serve as a bridge to adaptive immunity cells including T helper 1 cells, cytotoxic T cells and resident memory T cells. IFN-γ is the primary cytokine mediator that activates the JAK/STAT pathway, causing keratinocytes to produce the key chemokines CXCL9 and CXCL10. Complex interactions between immune and non-immune cells finally result in apoptosis of melanocytes. This paper summarizes current knowledge on the etiological and genetic factors that contribute to vitiligo, with a focus on immunopathogenesis and the key cellular and cytokine players in the disease’s inflammatory pathways.
Izvorni jezik
Engleski
POVEZANOST RADA
Profili:
Larisa Prpić Massari
(autor)
Ines Brajac
(autor)
Marija Kaštelan
(autor)
Nika Hlača
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus