Naslov
MiRNA in Molecular Diagnostics

Autori
Matulić, Maja ; Gršković, Paula ; Petrović, Andreja ; Begić, Valerija ; Harabajsa, Suzana ; Korać, Petra

Izvornik
Bioengineering (2306-5354) 9 (2022), 9; 459, 25

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
miRNA ; malignant tumors ; viral infections ; diagnostics

Sažetak
MicroRNAs are a class of small non-coding RNA molecules that regulate gene expression on post-transcriptional level. Their biogenesis consists of a complex series of sequential processes, and they regulate expression of many genes involved in all cellular processes. Their function is essential for maintaining the homeostasis of a single cell ; therefore, their aberrant expression contributes to development and progression of many diseases, especially malignant tumors and viral infections. Moreover, they can be associated with certain states of a specific disease, obtained in the least invasive manner for patients and analyzed with basic molecular methods used in clinical laboratories. Because of this, they have a promising potential to become very useful biomarkers and potential tools in personalized medicine approaches. In this review, miRNAs biogenesis, significance in cancer and infectious diseases, and current available test and methods for their detection are summarized.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA