Naslov
Butyrylcholinesterase with pralidoximeanalogs scavenges nerve agents

Autori
Čadež, Tena ; Zandona, Antonio ; Katalinić, Maja ; Kovarik, Zrinka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
FEBS Open Bio, 12 (Suppl. S1) / - : FEBS Press, 2022, 119-119

Skup
The Biochemistry Global Summit

Mjesto i datum
Lisabon, Portugal, 06.07.2022. - 14.07.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Organophosphorus compounds, acetylcholinesterase, butyrylcholesterase, pyridinium oximes, bioscavenging

Sažetak
Nerve agents’ (NA) neurotoxicity is primarily induced by phos-phorylation of acetylcholinesterase (AChE), the key enzyme inthe neurotransmitter acetylcholine (ACh) pathway. Its akinenzyme, butyrylcholinesterase (BChE), an enzyme without knownessential physiological function, can serve as a protector ofAChE from inhibition by NAs by binding them in a stoichiomet-ric ratio and thus lower their concentration in the body. Currenttherapy, consisting of compounds containing oxime group (i.e.pralidoxime) as reactivators of phosphorylated AChE, has lim-ited reactivation potency for phosphorylated BChE. Therefore, asearch for a BChE reactivator that would create an enzyme-oxime catalytic scavenging system is still ongoing. With that pur-pose, in this study, several pyridinium oximes were selected, tested, and identified as efficient reactivators for cyclosarin- inhib-ited BChE with up to 300-fold higher overall kinetic reactivation

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA