Naslov
Heterobimetallic complexes of ferrocene- dipyridylamine hybrids with cytotoxic activity

Autori
Jakopec, Silvio ; Pantalon Juraj, Natalija ; Kralj, Juran ; Brozovic, Anamaria ; Perić, Berislav ; Kirin, Srećko ; Raić-Malić, Silvana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXVll EFMC International Symposium on Medicinal Chemistry : Book of abstracts / - , 2022, 339-339

Skup
27th EFMC International Symposium on Medicinal Chemistry 2022 (EFMC-ISMC)

Mjesto i datum
Nica, Francuska, 04.09.2022. - 08.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
1, 2, 3-triazole ; ferrocene ; transition metal complex

Sažetak
Inorganic medicinal chemistry is a rapidly growing research area focused on the use of metal- containing drugs, inhibitors of metalloenzymes and metal complexes in the diagnosis of tumor and neurological diseases. The biological action of metal complexes is governed by catalytic activity, redox and photochemical properties and equilibrium reactions of a ligand and a metal ion that lead to the formation of biologically active species.1 Due to its stability, electrochemical properties and low toxicity, ferrocene is an important metallocene in the design of new chemotherapeutics.2 The introduction of ferrocene into biologically active compounds is carried out to increase the interaction of the drug with the receptor, which can be achieved by bioisosteric replacement of a phenyl group with ferrocene. The ferrocene subunit forms stronger interactions with the hydrophobic pocket of the biological target.3 Our recent work is focused on the synthesis and biological evaluation of heterobimetallic ferrocene complexes and their biological activity.4 Ferrocene derivatives of dipyridylamine and their Zn(II) and Cu(II) complexes were synthesized and their cytotoxic effect was explored on tumor cells. The Cu(II) complex with methylmethine linker between ferrocene and dipyridylamine showed the most prominent and selective cytotoxicity. Cell cycle analysis by flow cytometry revealed that the mechanism of cytotoxicity is dependent on the identity of the metal ion.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA