Naslov
Dual-Functional Polysaccharide Microgels Modulated by Therapeutic Metal Ions

Autori
Lončarević, Andrea ; Ostojić, Karla ; Klaser, Teodoro ; Urlić, Inga ; Rogina, Anamarija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, prošireni sažetak, znanstveni

Izvornik
32nd Annual Conference of the European Society for Biomaterials Book of Abstracts – Posters / - Bordeaux, 2022, 139-139

Skup
32nd Annual Conference of the European Society for Biomaterials

Mjesto i datum
Bordeaux, Francuska, 04.09.2022. - 08.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Polysaccharide ; Hydrogels ; Microgels ; Therapeutic Metal Ions

Sažetak
In recent years, chitosan-based materials modified by therapeutic metal ions gained much attention in regenerative medicine and tissue engineering due to the synergy of polymer’s biocompatibility and bioactivity of metal ions. Chitosan is a biocompatible, biodegradable and non-toxic cationic polysaccharide1 whose properties can be modulated by complexation with therapeutic metal ions such as cupric (Cu2+) or zinc (Zn2+) ions.2, 3 Cu2+ ions are well known for stimulating the proliferation and differentiation of human endothelial and mesenchymal stem cells, while Zn2+ ions promote bone formation by enhancing osteoblast differentiation.4 Furthermore, the complexation interactions between Cu2+ or Zn2+ ions with amino and hydroxyl groups, 5 leads to stable complex hydrogels. Combining biologically active ions with pH-responsive chitosan microspheres could generate multifunctional carriers and delivery systems. Still, there is no work focused on synthesis of Cu2+/Zn2+-chitosan complexes as microgels, i.e. in the form of microspheres. The aim of this work was to prepare and investigate the composition, morphology and cytotoxicity of Cu2+/Zn2+-chitosan complexes and their ability to form microgels using electrohydrodynamic atomization process. 1. Nie J. et al., Sci. Rep. 6:36005, 2016 2. Gritsch L. et al., J. Mater. Chem. B 7:6109-6124, 2019 3. Gamboa-Solana C. D. C. et al., Polymers (Basel) 13:3861, 2021 4. Mouriño V. et al., J. R. Soc. Interface 9:401-419, 2012 5. Guibal E., Sep. Purif. Technol. 38:43-74, 2004

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kemijsko inženjerstvo, Interdisciplinarne tehničke znanosti

POVEZANOST RADA