Naslov
Vancomycin-Resistant Enterococcus faecium Colonization and Clostridium difficile Infection in a Hematologic Patient

Autori
Goić Barišić, Ivana ; Radić, Marina ; Novak, Anita ; Rubić, Žana ; Boban, Nataša ; Lukšić, Boris ; Tonkić, Marija

Izvornik
Acta clinica Croatica (0353-9466) 59 (2020), 3; 523-528

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acute myelogenous leukemia ; Clostridium difficile ; Enterococcus faecium ; Vancomycin-resistant enterococcus

Sažetak
Vancomycin-resistant enterococci (VRE), especially Enterococcus faecium, have emerged as significant nosocomial pathogens and patients with impaired host defenses are at a particular risk of VRE infection. The most common occurrence is asymptomatic colonization of the gastrointestinal tract that can persist for a long time and serve as a reservoir for transmission of VRE to other patients. We present a case of a patient who was diagnosed with acute myelogenous leukemia and suffered from bone marrow aplasia following induction therapy. The patient received prolonged broad-spectrum antimicrobial therapy. During hospital stay, the patient developed Clostridium difficile infection (CDI) and was found to be colonized with a strain of Enterococcus faecium resistant to vancomycin during therapy for CDI. This case also highlights the role of risk factors that could contribute to development of resistance, particularly CDI. Early detection of VRE colonization or infection is a crucial component in hospital program designed to prevent transmission of nosocomial infections. Surveillance cultures of such patients should be mandatory.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA