Pregled bibliografske jedinice broj: 1212967
Terpenes and Cannabinoids in Supercritical CO2 Extracts of Industrial Hemp Inflorescences: Optimization of Extraction, Antiradical and Antibacterial Activity
Terpenes and Cannabinoids in Supercritical CO2 Extracts of Industrial Hemp Inflorescences: Optimization of Extraction, Antiradical and Antibacterial Activity // Pharmaceuticals, 15 (2022), 9; 1117, 21 doi:10.3390/ph15091117 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1212967 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Terpenes and Cannabinoids in Supercritical CO2
Extracts of Industrial Hemp Inflorescences:
Optimization of Extraction, Antiradical and
Antibacterial Activity
(Terpenes and Cannabinoids in Supercritical CO2
Extracts of Industrial Hemp Inflorescences:
Optimization of Extraction, Antiradical and
Antibacterial Activity)
Autori
Jokić, Stela ; Jerković, Igor ; Pavić, Valentina ; Aladić, Krunoslav ; Molnar, Maja ; Jakovljević Kovač, Martina ; Vladimir-Knežević, Sanda
Izvornik
Pharmaceuticals (1424-8247) 15
(2022), 9;
1117, 21
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Cannabis sativa ; industrial hemp ; supercritical CO2 extraction ; terpenes ; cannabinoids ; antiradical activity ; antibacterial activity
Sažetak
Natural products are increasingly in demand in dermatology and cosmetology. In the present study, highly valuable supercritical CO2 (sCO2) extracts rich in bioactive compounds with antiradical and antibacterial activity were obtained from the inflorescences of industrial hemp. Volatile compounds were analyzed by gas chromatography in tandem with mass spectrometry (GCMS), while cannabinoids were determined by high performance liquid chromatography (HPLC DAD). Extraction yields varied from 0.75 to 8.83%, depending on the pressure and temperature applied. The extract obtained at 320 bar and 40 °C with the highest content (305.8 µg mg−1) of cannabidiolic acid (CBDA) showed the best antiradical properties. All tested extract concentrations from 10.42 µg mL−1 to 66.03 µg mL−1 possessed inhibitory activities against E. coli, P. aeruginosa, B. subtilis, and S. aureus. The sCO2 extract with the highest content of cannabidiol (CBD) and rich in αpinene, β-pinene, β-myrcene, and limonene was the most effective. The optimal conditions for sCO2 extraction of cannabinoids and volatile terpenes from industrial hemp were determined. The temperature of 60 °C proved to be optimal for all responses studied, while the pressure showed a different effect depending on the compounds targeted. A low pressure of 131.2 bar was optimal for the extraction of monoterpenes, while extracts rich in sesquiterpenes were obtained at 319.7 bar. A high pressure of 284.78 bar was optimal for the extraction of CBD.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
POVEZANOST RADA
Projekti:
MRRFEU-KK.01.1.1.02.0010 - Tehnološko inovacijski centar Virovitica (Jokić, Stela, MRRFEU ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Kemijsko-tehnološki fakultet, Split,
Prehrambeno-tehnološki fakultet, Osijek,
Sveučilište u Osijeku - Odjel za biologiju
Profili:
Maja Molnar
(autor)
Igor Jerković
(autor)
Valentina Pavić
(autor)
Krunoslav Aladić
(autor)
Martina Jakovljević Kovač
(autor)
Sanda Vladimir-Knežević
(autor)
Stela Jokić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus