Naslov
New-onset ocular myasthenia gravis after booster dose of COVID-19 vaccine

Autori
Abičić, Ana ; Sitas, Barbara ; Adamec, Ivan ; Bilić, Ervina ; Habek, Mario

Izvornik
Cureus (2168-8184) 14 (2022), 7; E27213, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
autoimmune diseases ; bnt162 vaccine ; covid-19 vaccines ; diplopia ; myasthenia gravis

Sažetak
Coronavirus disease 2019 (COVID-19) vaccines have been reported as possible triggers of the production of antibodies pathogenic to the peripheral nerve and neuromuscular junction. We report on a patient who experienced vertical diplopia three weeks after the booster dose of the Pfizer-BioNTech vaccine (Comirnaty®). The diagnosis of myasthenia gravis (MG) was established based on highly positive antibodies to the nicotinic acetylcholine receptor (nAChR). Treatment with pyridostigmine and prednisone was started with gradually raising doses. On a follow- up exam two months after treatment initiation, clinical improvement was noted with an almost normal bulbomotor examination. The occurrence of diplopia following COVID-19 vaccination should raise suspicion of new-onset ocular MG and testing for anti-nAChR antibodies is advised.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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