Pregled bibliografske jedinice broj: 1211498
Fluid-Solid-Growth model of thrombus deposited Abdominal Aortic Aneurysm
Fluid-Solid-Growth model of thrombus deposited Abdominal Aortic Aneurysm // Euromech Colloquium 627: Current Challenges In Soft Tissue Mechanics
Frankfurt na Majni, Njemačka, 2022. (predavanje, nije recenziran, neobjavljeni rad, znanstveni)
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Naslov
Fluid-Solid-Growth model of thrombus deposited
Abdominal Aortic Aneurysm
Autori
Živić Josip ; Horvat, Nino ; Karšaj, Igor
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni
Skup
Euromech Colloquium 627: Current Challenges In Soft Tissue Mechanics
Mjesto i datum
Frankfurt na Majni, Njemačka, 06.04.2022. - 08.04.2022
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
Abdominal aortic aneurysm, biomechanics, Growth and remodeling
Sažetak
Abdominal aortic aneurysm (AAA) is widespread disease in the overall population and more and more effort is being put into its treatment. The majority of AAAs harbor intraluminal thrombi (ILT), which has biochemomechanically active role in growth and remodeling (G&R) of AAA [1] and shows diverse effects on the AAA enlargement. ILT decreases peak wall stress but on the other hand biochemically degrades and weakens the wall. The model will couple hemodynamics with growth of AAA with ILT, and will consider thrombus complex mechanical effects. Knowing the right model of AAA, ILT growth and hemodynamics is of great importance because it allows broaden understanding of the further disease course. Bloodflow through AAA is directly related to ILT formation, and computational fluid dynamics (CFD) simulations outcome is directly used to determine whether an ILT will be deposited (figure 1.), as well as to predict the location and amount of its accumulation. Thrombus accumulation is predicted based on time averaged wall shear stress [2] on luminal surface. Bloodflow model plays crucial role because ILT settles differently compared to non-fluid G&R models. Both G&R theory and CFD simulations are run iteratively and represents the right and realistic behavior of blood vessel system, known also as fluid-solid growth model. The G&R model is based on the constraint mixture theory and the theory of evolving configurations to describe changes in geometry and structure of aorta. The aortic wall is assumed to comprise of isotropic elastin, four collagen fiber families, and circumferentially oriented smooth muscle cells. The constrained mixture G&R model is implemented into finite element analysis program FEAP via subroutines for the user defined material model [3]. Augmented Lagrange method was used to obtained incompressibility. Blood was modeled as a Non-Newtonian fluid with implemented Bird-Carreau viscosity model into OpenFOAM ; a finite volume software package.
Izvorni jezik
Engleski
Znanstvena područja
Strojarstvo
POVEZANOST RADA
Projekti:
HRZZ-IP-2020-02-4016 - Numerička procjena rizika od rupture nekomplicirane disekcije aorte tipa B (LessPatients) (Tuković, Željko, HRZZ - 2020-02) ( CroRIS)