Pregled bibliografske jedinice broj: 1211456
Distinct Cytokine Profiles in Severe COVID-19 and Non-Alcoholic Fatty Liver Disease
Distinct Cytokine Profiles in Severe COVID-19 and Non-Alcoholic Fatty Liver Disease // Life, 12 (2022), 6; 795, 13 doi:10.3390/life12060795 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1211456 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Distinct Cytokine Profiles in Severe COVID-19 and
Non-Alcoholic Fatty Liver Disease
Autori
Papić, Neven ; Šamadan, Lara ; Vrsaljko, Nina ; Radmanić, Leona ; Jeličić, Karlo ; Šimičić, Petra ; Svoboda, Petra ; Židovec Lepej, Snježana ; Vince, Adriana
Izvornik
Life (2075-1729) 12
(2022), 6;
795, 13
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
COVID-19 ; NAFLD ; SARS-CoV2 ; inflammation ; cytokines ; interleukin-6 ; interleukin-8 ; interferons ; MAFLD ; obesity
Sažetak
Non-alcoholic fatty liver disease (NAFLD) is identified as a risk factor for developing severe COVID-19. While NAFLD is associated with chronic low- grade inflammation, mechanisms leading to immune system hyperactivation remain unclear. The aim of this prospective observational study is to analyze cytokine profiles in patients with severe COVID-19 and NAFLD. A total of 94 patients with severe COVID- 19 were included. Upon admission, clinical and laboratory data were collected, a liver ultrasound was performed to determine the presence of steatosis, and subsequently, 51 were diagnosed with NAFLD according to the current guidelines. There were no differences in age, sex, comorbidities, and baseline disease severity between the groups. Serum cytokine concentrations were analyzed using a multiplex bead- based assay by flow cytometry. Upon admission, the NAFLD group had higher C-reactive protein, procalcitonin, alanine aminotransferase, lactate dehydrogenase, and fibrinogen. Interleukins-6, -8, and -10 and CXCL10 were significantly higher, while IFN-γ was lower in NAFLD patients. Patients with NAFLD who progressed to critical illness had higher concentrations of IL-6, -8, -10, and IFN-β, and IL-8 and IL-10 appear to be effective prognostic biomarkers associated with time to recovery. In conclusion, NAFLD is associated with distinct cytokine profiles in COVID-19, possibly associated with disease severity and adverse outcomes.
Izvorni jezik
Engleski
Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
UIP-2019-04-7194 - Uloga imunih semaforina u nealkoholnoj masnoj bolesti jetre i sepsi (SepsisFAT) (Papić, Neven, HRZZ - 2019-04) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević"
Profili:
Petra Svoboda
(autor)
Neven Papić
(autor)
Leona Radmanic
(autor)
Snježana Židovec-Lepej
(autor)
Petra Simicic
(autor)
Adriana Vince
(autor)
Lara Šamadan
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus