Naslov
Application of flow chemistry in process development of active pharmaceutical ingredients (APIs)

Autori
Mastelić Samardžić Zrinka, Mihovilović Moris, Wittine Ozren, Omerbašić Aida, Vušak Vitomir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
26. Croatian Meeting of Chemists and Chemical Engineers, Book of Abstracts / Galić Nives, Rogošić Marko - Zagreb, 2019, 160-160

Skup
26. hrvatski skup kemičara i kemijskih inženjera (26HSKIKI) ; 4. simpozij Vladimir Prelog

Mjesto i datum
Šibenik, Hrvatska, 09.04.2019. - 12.04.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Protočna kemija, organska sinteza, API
(Flow chemistry, organic synthesis, API)

Sažetak
The concept of "flow chemistry" defines a general range of chemical processes that occur in a continuous flowing stream, conventionally taking place in a reactor zone. The application of flow chemistry relies on the concept of pumping reagents using many reactors types to perform specific reactions. The most common types of reactors are plug flow reactors and column reactors, whilst for specific chemistries more sophisticated reactor designs might be needed. Flow equipment provides chemists with unique control over reaction parameters enhancing reactivity, increasing process safety or in some cases enabling new reactions. In cases when processes in batch give unsatisfactory results regarding: yield, purity, safety, harsh reaction conditions and/or high costs, the solution can be found in transferring the reaction in the flow process. This work represents different examples of transfer of batch processes to flow. All reactions that will be presented were tested on the laboratory scale during development of processes for active pharmaceutical ingredients (API) synthesis in Pliva R&D. The aim of this work is to summarize advantages and disadvantages of flow processes. Main problems and challenges that were experienced during batch to flow transfer will be specially pointed out. All experiments were performed in a Vapourtec flow RS400 system in different types of tube and chip reactors depending of type of tested reaction (Figure 1). Reactions which gave the best results in flow are going to be considered as candidates for further development and scale up.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kemijsko inženjerstvo

POVEZANOST RADA