Naslov
Polygenic Risk Score and Risk Factors for Gestational Diabetes

Autori
Perišić, Marija Majda ; Vladimir, Klemo ; Karpov, Sarah ; Štorga, Mario ; Mostashari, Ali ; Khanin, Raya

Izvornik
Journal of personalized medicine (2075-4426) 12 (2022), 9; 1381, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
gestational diabetes ; pregnancy ; polygenic risk score ; gwas ; machine learning

Sažetak
Gestational diabetes mellitus (GDM) is a common complication of pregnancy that adversely affects maternal and offspring health. A variety of risk factors, such as BMI and age, have been associated with increased risks of gestational diabetes. However, in many cases, gestational diabetes occurs in healthy nulliparous women with no obvious risk factors. Emerging data suggest that the tendency to develop gestational diabetes has genetic and environmental components. Here we develop a polygenic risk score for GDM and investigate relationships between its genetic architecture and genetically constructed risk factors and biomarkers. Our results demonstrate that the polygenic risk score can be used as an early screening tool that identifies women at higher risk of GDM before its onset allowing comprehensive monitoring and preventative programs to mitigate the risks.

Izvorni jezik
Engleski

Znanstvena područja
Računarstvo, Temeljne medicinske znanosti

POVEZANOST RADA