Naslov
Azithromycin modulates neutrophil function and circulating inflammatory mediators in healthy human subjects

Autori
Čulić, Ognjen ; Eraković, Vesna ; Čepelak, Ivana ; Barišić, Karmela ; Brajša, Karmen ; Ferenčić, Željko ; Galović, Ružica ; Glojnarić, Ines ; Manojlović, Zoran ; Munić, Vesna ; Novak-Mirčetić, Renata ; Pavičić-Beljak, Verica ; Sučić, Mirna ; Veljača, Marija ; Žanić-Grubišić, Tihana ; Parnham, Michael

Izvornik
European journal of pharmacology (0014-2999) 450 (2002), 3; 277-289

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Azithromycin ; Neutrophil ; Human volunteers ; Degranulation ; Oxidative burst ; Cytokine

Sažetak
Effects on human neutrophils and circulating inflammatory mediators were studied in 12 volunteers who received azithromycin (500 mg/day, p.o.) for 3 days. Blood was taken 1 h before treatment, 2.5, 24 h and 28 days after the last dose. An initial neutrophil degranulating effect of azithromycin was reflected in rapid decreases in azurophilic granule enzyme activities in cells and corresponding increases in serum. The oxidative response to a particulate stimulus was also acutely enhanced. These actions were associated with high plasma and neutrophil drug concentrations. A continuous fall in chemokine and interleukin-6 serum concentrations, within the non-pathological range, accompanied a delayed down-regulation of the oxidative burst and an increase in apoptosis of neutrophils up to 28 days after the last azithromycin dose. Neutrophils isolated from blood at this time point still contained detectable drug concentrations. Acute neutrophil stimulation could facilitate antibacterial effects of azithromycin, while delayed, potentially anti-inflammatory activity may curtail deleterious inflammation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA