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Pregled bibliografske jedinice broj: 1207916

Effect of Tff3 protein deficiency on expression of neurodegeneration-associated genes in hippocampi of aged mice


Anušić, Lucija
Effect of Tff3 protein deficiency on expression of neurodegeneration-associated genes in hippocampi of aged mice, 2021., diplomski rad, diplomski, Prirodoslovno-matematički fakultet, Biološki odsjek, Zagreb


CROSBI ID: 1207916 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Effect of Tff3 protein deficiency on expression of neurodegeneration-associated genes in hippocampi of aged mice
(Učinak nedostatka proteina Tff3 na ekspresiju gena povezanih s neurodegeneracijom hipokampusa u mišjem modelu starenja)

Autori
Anušić, Lucija

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski

Fakultet
Prirodoslovno-matematički fakultet, Biološki odsjek

Mjesto
Zagreb

Datum
24.09

Godina
2021

Stranica
35

Mentor
Baus Lončar, Mirela ; Blažević, Sofia Ana

Ključne riječi
Bdnf ; Egfr ; Epac2, hipokampus ; L1cam ; neurogeneza ; neuroplastičnost ; Nfl
(Bdnf ; Egfr ; Epac2 ; hippocampus ; L1cam ; neurogenesis ; neuroplasticity ; Nfl)

Sažetak
The increase in the incidence of neurodegenerative diseases is a reflection of complex cumulative processes during aging which involve the interactions of numerous organ systems. Decreased levels of Trefoil factor 3 (Tff3) protein in the cerebrospinal fluid of patients with Alzheimer’s disease indicate its possible role in neurodegenerative processes. Tff3 is involved in a variety of processes such as healing of mucosal surfaces in the gastrointestinal tract and apoptosis, migration, and angiogenesis, while its role in neural tissue is still unknown. In this paper, we hypothesized that Tff3 protein deficiency leads to a greater affinity of mice for the development of neurodegenerative processes, which we measured through the relative expression of the following genes:brain-derived neurotrophic factor (Bdnf), exchange protein directly activated by cAMP 2 (Epac2), epidermal growth factor receptor (Egfr), neurofilament light protein (Nfl) and L1 cell adhesion molecule (L1cam). Two - year - old mice of the Tff3 -/- C57Bl6/NCrl genotype and appropriate Wt controls were used in this study. Our results showed that Tff3 protein deficiency does not affect the expression of the observed genes involved in neurodegenerative processes.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-2717 - TFF3 protein na raskrižju metabolizma i neurodegeneracije (Inter MeNe-3) (Baus Lončar, Mirela, HRZZ - 2016-06) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Sofia Ana Blažević (mentor)

Avatar Url Mirela Baus Lončar (mentor)

Citiraj ovu publikaciju:

Anušić, Lucija
Effect of Tff3 protein deficiency on expression of neurodegeneration-associated genes in hippocampi of aged mice, 2021., diplomski rad, diplomski, Prirodoslovno-matematički fakultet, Biološki odsjek, Zagreb
Anušić, L. (2021) 'Effect of Tff3 protein deficiency on expression of neurodegeneration-associated genes in hippocampi of aged mice', diplomski rad, diplomski, Prirodoslovno-matematički fakultet, Biološki odsjek, Zagreb.
@phdthesis{phdthesis, author = {Anu\v{s}i\'{c}, Lucija}, year = {2021}, pages = {35}, keywords = {Bdnf, Egfr, Epac2, hipokampus, L1cam, neurogeneza, neuroplasti\v{c}nost, Nfl}, title = {Effect of Tff3 protein deficiency on expression of neurodegeneration-associated genes in hippocampi of aged mice}, keyword = {Bdnf, Egfr, Epac2, hipokampus, L1cam, neurogeneza, neuroplasti\v{c}nost, Nfl}, publisherplace = {Zagreb} }
@phdthesis{phdthesis, author = {Anu\v{s}i\'{c}, Lucija}, year = {2021}, pages = {35}, keywords = {Bdnf, Egfr, Epac2, hippocampus, L1cam, neurogenesis, neuroplasticity, Nfl}, title = {U\v{c}inak nedostatka proteina Tff3 na ekspresiju gena povezanih s neurodegeneracijom hipokampusa u mi\v{s}jem modelu starenja}, keyword = {Bdnf, Egfr, Epac2, hippocampus, L1cam, neurogenesis, neuroplasticity, Nfl}, publisherplace = {Zagreb} }




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