Pregled bibliografske jedinice broj: 1207916
Effect of Tff3 protein deficiency on expression of neurodegeneration-associated genes in hippocampi of aged mice
Effect of Tff3 protein deficiency on expression of neurodegeneration-associated genes in hippocampi of aged mice, 2021., diplomski rad, diplomski, Prirodoslovno-matematički fakultet, Biološki odsjek, Zagreb
CROSBI ID: 1207916 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Effect of Tff3 protein deficiency on expression of
neurodegeneration-associated genes in hippocampi
of aged mice
(Učinak nedostatka proteina Tff3 na ekspresiju gena
povezanih s neurodegeneracijom hipokampusa u
mišjem modelu starenja)
Autori
Anušić, Lucija
Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski
Fakultet
Prirodoslovno-matematički fakultet, Biološki odsjek
Mjesto
Zagreb
Datum
24.09
Godina
2021
Stranica
35
Mentor
Baus Lončar, Mirela ; Blažević, Sofia Ana
Ključne riječi
Bdnf ; Egfr ; Epac2, hipokampus ; L1cam ; neurogeneza ; neuroplastičnost ; Nfl
(Bdnf ; Egfr ; Epac2 ; hippocampus ; L1cam ; neurogenesis ; neuroplasticity ; Nfl)
Sažetak
The increase in the incidence of neurodegenerative diseases is a reflection of complex cumulative processes during aging which involve the interactions of numerous organ systems. Decreased levels of Trefoil factor 3 (Tff3) protein in the cerebrospinal fluid of patients with Alzheimer’s disease indicate its possible role in neurodegenerative processes. Tff3 is involved in a variety of processes such as healing of mucosal surfaces in the gastrointestinal tract and apoptosis, migration, and angiogenesis, while its role in neural tissue is still unknown. In this paper, we hypothesized that Tff3 protein deficiency leads to a greater affinity of mice for the development of neurodegenerative processes, which we measured through the relative expression of the following genes:brain-derived neurotrophic factor (Bdnf), exchange protein directly activated by cAMP 2 (Epac2), epidermal growth factor receptor (Egfr), neurofilament light protein (Nfl) and L1 cell adhesion molecule (L1cam). Two - year - old mice of the Tff3 -/- C57Bl6/NCrl genotype and appropriate Wt controls were used in this study. Our results showed that Tff3 protein deficiency does not affect the expression of the observed genes involved in neurodegenerative processes.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-IP-2016-06-2717 - TFF3 protein na raskrižju metabolizma i neurodegeneracije (Inter MeNe-3) (Baus Lončar, Mirela, HRZZ - 2016-06) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb