Pregled bibliografske jedinice broj: 1207709
Analysis of polymorphisms in EGF, EGFR and HER2 genes in pancreatic neuroendocrine tumors (PNETs)
Analysis of polymorphisms in EGF, EGFR and HER2 genes in pancreatic neuroendocrine tumors (PNETs) // Cancer Genetics, 266-267 (2022), 44-50 doi:10.1016/j.cancergen.2022.06.005 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1207709 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Analysis of polymorphisms in EGF, EGFR and HER2 genes in pancreatic neuroendocrine tumors (PNETs)
Autori
Marinović, Sonja ; Cigrovski Berković, Maja ; Zjačić-Rotkvić, Vanja ; Kapitanović, Sanja
Izvornik
Cancer Genetics (2210-7762) 266-267
(2022);
44-50
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
pancreatic neuroendocrine tumors ; EGFEGFRHER2 metastasis
Sažetak
Objectives Pancreatic neuroendocrine tumors (NETs) are rare and account for about 7% of all cancers occurring in the pancreas. The epidermal growth factor family of receptors and their ligands play an important role in the growth and progression of tumors but their role in PNET development remains unknown. We hypothesized that functional single nucleotide polymorphisms (SNPs) in the EGF, EGFR, and HER2 genes might affect individual susceptibility to PNETs development and invasion like it was shown for various other tumors. Methods We genotyped 68 patients with unresectable PNETs and 300 controls to evaluate the association between EGF, EGFR, and HER2 polymorphisms and susceptibility to PNETs and presence of metastases. Results Genotype analysis of three SNPs EGF +61A/G (rs4444903), EGFR +1562 G/A (rs11543848), and HER2 +1963 A/G (rs1136201) showed that carriers of EGFR +1562 AG genotype and AA/AG EGF +61/HER2 +1963 genotype combination are at risk of developing PNET. Furthermore, EGFR +1562 AA genotype could be associated with the susceptibility to insulinoma development. Conclusions Our results suggest involvement of EGFR signaling pathway in etiology of PNET development.
Izvorni jezik
Engleski
Znanstvena područja
Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Projekti:
MZOS-134-1342428-0491 - Neuroendokrini tumori probavnog sustava i gušterače (Cigrovski Berković, Maja, MZOS ) ( CroRIS)
MZOS-098-0982464-2508 - Molekularna genetika i farmakogenetika gastrointestinalnih tumora (Kapitanović, Sanja, MZOS ) ( CroRIS)
HRZZ-IP-2016-06-1430 - Mikrosatelitna nestabilnost (MSI i EMAST) u molekularnom profiliranju sporadičnih karcinoma debelog crijeva (MSIandEMASTinCRC) (Kapitanović, Sanja, HRZZ - 2016-06) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
KBC "Sestre Milosrdnice",
Klinička bolnica "Dubrava"
Profili:
Sanja Kapitanović
(autor)
Vanja Zjačić-Rotkvić
(autor)
Sonja Marinović
(autor)
Maja Cigrovski Berković
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE