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Pregled bibliografske jedinice broj: 1207709

Analysis of polymorphisms in EGF, EGFR and HER2 genes in pancreatic neuroendocrine tumors (PNETs)


Marinović, Sonja; Cigrovski Berković, Maja; Zjačić-Rotkvić, Vanja; Kapitanović, Sanja
Analysis of polymorphisms in EGF, EGFR and HER2 genes in pancreatic neuroendocrine tumors (PNETs) // Cancer Genetics, 266-267 (2022), 44-50 doi:10.1016/j.cancergen.2022.06.005 (međunarodna recenzija, članak, znanstveni)


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Naslov
Analysis of polymorphisms in EGF, EGFR and HER2 genes in pancreatic neuroendocrine tumors (PNETs)

Autori
Marinović, Sonja ; Cigrovski Berković, Maja ; Zjačić-Rotkvić, Vanja ; Kapitanović, Sanja

Izvornik
Cancer Genetics (2210-7762) 266-267 (2022); 44-50

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
pancreatic neuroendocrine tumors ; EGFEGFRHER2 metastasis

Sažetak
Objectives Pancreatic neuroendocrine tumors (NETs) are rare and account for about 7% of all cancers occurring in the pancreas. The epidermal growth factor family of receptors and their ligands play an important role in the growth and progression of tumors but their role in PNET development remains unknown. We hypothesized that functional single nucleotide polymorphisms (SNPs) in the EGF, EGFR, and HER2 genes might affect individual susceptibility to PNETs development and invasion like it was shown for various other tumors. Methods We genotyped 68 patients with unresectable PNETs and 300 controls to evaluate the association between EGF, EGFR, and HER2 polymorphisms and susceptibility to PNETs and presence of metastases. Results Genotype analysis of three SNPs EGF +61A/G (rs4444903), EGFR +1562 G/A (rs11543848), and HER2 +1963 A/G (rs1136201) showed that carriers of EGFR +1562 AG genotype and AA/AG EGF +61/HER2 +1963 genotype combination are at risk of developing PNET. Furthermore, EGFR +1562 AA genotype could be associated with the susceptibility to insulinoma development. Conclusions Our results suggest involvement of EGFR signaling pathway in etiology of PNET development.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
MZOS-134-1342428-0491 - Neuroendokrini tumori probavnog sustava i gušterače (Cigrovski Berković, Maja, MZOS ) ( CroRIS)
MZOS-098-0982464-2508 - Molekularna genetika i farmakogenetika gastrointestinalnih tumora (Kapitanović, Sanja, MZOS ) ( CroRIS)
HRZZ-IP-2016-06-1430 - Mikrosatelitna nestabilnost (MSI i EMAST) u molekularnom profiliranju sporadičnih karcinoma debelog crijeva (MSIandEMASTinCRC) (Kapitanović, Sanja, HRZZ - 2016-06) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
KBC "Sestre Milosrdnice",
Klinička bolnica "Dubrava"

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Marinović, Sonja; Cigrovski Berković, Maja; Zjačić-Rotkvić, Vanja; Kapitanović, Sanja
Analysis of polymorphisms in EGF, EGFR and HER2 genes in pancreatic neuroendocrine tumors (PNETs) // Cancer Genetics, 266-267 (2022), 44-50 doi:10.1016/j.cancergen.2022.06.005 (međunarodna recenzija, članak, znanstveni)
Marinović, S., Cigrovski Berković, M., Zjačić-Rotkvić, V. & Kapitanović, S. (2022) Analysis of polymorphisms in EGF, EGFR and HER2 genes in pancreatic neuroendocrine tumors (PNETs). Cancer Genetics, 266-267, 44-50 doi:10.1016/j.cancergen.2022.06.005.
@article{article, author = {Marinovi\'{c}, Sonja and Cigrovski Berkovi\'{c}, Maja and Zja\v{c}i\'{c}-Rotkvi\'{c}, Vanja and Kapitanovi\'{c}, Sanja}, year = {2022}, pages = {44-50}, DOI = {10.1016/j.cancergen.2022.06.005}, keywords = {pancreatic neuroendocrine tumors, EGFEGFRHER2 metastasis}, journal = {Cancer Genetics}, doi = {10.1016/j.cancergen.2022.06.005}, volume = {266-267}, issn = {2210-7762}, title = {Analysis of polymorphisms in EGF, EGFR and HER2 genes in pancreatic neuroendocrine tumors (PNETs)}, keyword = {pancreatic neuroendocrine tumors, EGFEGFRHER2 metastasis} }
@article{article, author = {Marinovi\'{c}, Sonja and Cigrovski Berkovi\'{c}, Maja and Zja\v{c}i\'{c}-Rotkvi\'{c}, Vanja and Kapitanovi\'{c}, Sanja}, year = {2022}, pages = {44-50}, DOI = {10.1016/j.cancergen.2022.06.005}, keywords = {pancreatic neuroendocrine tumors, EGFEGFRHER2 metastasis}, journal = {Cancer Genetics}, doi = {10.1016/j.cancergen.2022.06.005}, volume = {266-267}, issn = {2210-7762}, title = {Analysis of polymorphisms in EGF, EGFR and HER2 genes in pancreatic neuroendocrine tumors (PNETs)}, keyword = {pancreatic neuroendocrine tumors, EGFEGFRHER2 metastasis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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