Naslov
Synthesis of naphtho/thienobenzo-triazoles by photocyclization

Autori
Mlakić, Milena ; Škorić, Irena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
28th IUPAC Symposium on Photochemistry

Mjesto i datum
Amsterdam, Nizozemska, 17.07.2022. - 22.07.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Photocyclization ; Naphtho-triazoles ; Thienobenzo-triazoles ; Photochemical methodology
(fotociklizacija ; nafto-triazoli ; tienobenzo-triazoli ; fotokemijska metodologija)

Sažetak
Promising test results on the biological activity of our previously described naphtho-triazoles, obtained by the photochemical cyclization of 1, 2, 3-triazolostilbenes, prompted us to continue with the photochemical synthesis of new substituted electrocyclization products. At the same time, we investigated the mechanisms of E-Z photoisomerizations of the starting 1, 2, 3- triazolostilbenes and oxazolostilbenes followed by photocyclization via dihydro intermediates. In the current work, the synthesis of novel naphtho- triazoles and thienobenzo-triazoles by photocyclization is investigated in order to achieve complete conversion toward the targeted scaffold. Efficient photochemical methodology and isolated yields in photocyclization will be crucial for the application of these new naphtho- triazoles and thienobenzo-triazoles as potential acetyl- and butyrylcholinesterase inhibitors with the anti- inflammatory activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA