Naslov
Inhibition of the HIV-1 Rev-RRE Complex Formation by Unfused Aromatic Cations

Autori
Xiao, Ge ; Kumar, Arvind ; Li, Ke ; Rigl, C Ted ; Bajić, Miroslav ; Davis, Tina M ; Boykin, David W ; Wilson W David

Izvornik
Bioorganic & medicinal chemistry (0968-0896) 9 (2001), 5; 1097-1113

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
small molecules; ribosomal-RNA; responsive element; recognize RNA; drug target; binding; antibiotics; tat; protein; design

Sažetak
RNA viruses cause a wide range of human diseases. Development of new agents to target such viruses is an active area of research. Towards this goal, a series of diphenylfuran cations as potential inhibitors of the Rev-RRE complex have been designed and synthesized. Analysis of the interaction of the diphenylfurans with RRE and TAR RNA model systems by gel shift assays indicates that they exhibit both sequence and structure-dependent binding modes. Our results show a strong interaction between the diphenylfuran ring system and RRE bases, while the TAR interactions are much weaker with the compounds that are the best inhibitors of Rev-RRE.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA