Naslov
Effect of gangliosides on the copper-induced oxidation of human low-density lipoproteins

Autori
Kveder, Marina ; Pifat, Greta ; Gavella, Mirjana ; Lipovac, Vaskresenija

Izvornik
Biophysical chemistry (0301-4622) 104 (2003), 1; 45-54

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
LDL ; Gangliosides ; Oxidation ; Fluorescence

Sažetak
The role of gangliosides in the copper-induced oxidative modification of human low-density lipoprotein (LDL) was studied focusing on the early stage of LDL oxidation in which the concnetration of conjugsated dienes increases only weakly. The changes in the protein and lipid component were followed using fluorescence spectroscopy. The results indicate that binding of gangliosides to LDL causes slower destruction of tryptophan fluorescence and suppresses cross-linking between the rreactive groups of the protein and the products of lipid peroxidation. The protective role of gangliosides could be assigned to their interference with the lipid-protein interaction in the LDL particle, which might be important for the maintenance of the native plasma antioxidant status in vivo.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA