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Pregled bibliografske jedinice broj: 1205439

Resistome Analysis of Campylobacter jejuni Strains Isolated from Human Stool and Primary Sterile Samples in Croatia


Šoprek, Silvija; Duvnjak, Sanja; Kompes, Gordan; Jurinović, Luka; Tambić Andrašević, Arjana
Resistome Analysis of Campylobacter jejuni Strains Isolated from Human Stool and Primary Sterile Samples in Croatia // Microorganisms, 10 (2022), 7; 1410, 13 doi:10.3390/ microorganisms10071410 (međunarodna recenzija, članak, znanstveni)


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Naslov
Resistome Analysis of Campylobacter jejuni Strains Isolated from Human Stool and Primary Sterile Samples in Croatia

Autori
Šoprek, Silvija ; Duvnjak, Sanja ; Kompes, Gordan ; Jurinović, Luka ; Tambić Andrašević, Arjana

Izvornik
Microorganisms (2076-2607) 10 (2022), 7; 1410, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Campylobacter jejuni ; antimicrobial resistance ; antimicrobial susceptibility testing ; bioinformatics ; whole genome sequencing ; Campylobacter jejuni in primary sterile samples

Sažetak
Campylobacteriosis represents a global health challenge due to continuously increasing trends of antimicrobial resistance in Campylobacter jejuni. C. jejuni can sometimes cause life-threatening and severe systematic infections (bacteremia, meningitis, and other extraintestinal infections) with very few antibiotics left as treatment options. Bearing in mind that C. jejuni is the predominant species in humans, in this paper, we present a study of the C. jejuni differences in antimicrobial resistance and genotype distribution between strains isolated from stool and primary sterile sites. We compared the genomic data obtained through whole genome sequencing (WGS) and phenotypic susceptibility data of C. jejuni strains. Once antimicrobial susceptibility testing of C. jejuni strains was carried out by the broth microdilution method for six of interest, results were compared to the identified genotypic determinants derived from WGS. The high rate of resistance to fluoroquinolones presented in this study is in accordance with national surveillance data. The proportion of strains with acquired resistance was 71% for ciprofloxacin and 20% for tetracycline. When invasive isolates were analysed separately, 40% exhibited MIC values of ciprofloxacin higher than the ECOFFs, suggesting a lower flouroquinolone resistance rate in invasive isolates. All isolates demonstrated wilde-type phenotype for chloramphenicol, erythromycin, gentamicin, and ertapenem. A special focus and review in this study was performed on a group of C.jejuni strains found in primary sterile samples. Apart from demonstrating a lower resistance rate, these isolates seem genetically more uniform, showing epidemiologically more homogenous patterns, which cluster to several clonal complexes, with CC49 being the most represented clonal complex

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekti:
HRZZ-UIP-2020-02-2528 - Epidemiologija bakterije Campylobacter jejuni u galebova klaukavaca, Larus michahellis u Hrvatskoj, kroz koncept „Jedno zdravlje“ (EpiCGulls) (Jurinovic, Luka, HRZZ - 2020-02) ( CroRIS)

Ustanove:
Hrvatski veterinarski institut, Zagreb,
Stomatološki fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.mdpi.com

Citiraj ovu publikaciju:

Šoprek, Silvija; Duvnjak, Sanja; Kompes, Gordan; Jurinović, Luka; Tambić Andrašević, Arjana
Resistome Analysis of Campylobacter jejuni Strains Isolated from Human Stool and Primary Sterile Samples in Croatia // Microorganisms, 10 (2022), 7; 1410, 13 doi:10.3390/ microorganisms10071410 (međunarodna recenzija, članak, znanstveni)
Šoprek, S., Duvnjak, S., Kompes, G., Jurinović, L. & Tambić Andrašević, A. (2022) Resistome Analysis of Campylobacter jejuni Strains Isolated from Human Stool and Primary Sterile Samples in Croatia. Microorganisms, 10 (7), 1410, 13 doi:10.3390/ microorganisms10071410.
@article{article, author = {\v{S}oprek, Silvija and Duvnjak, Sanja and Kompes, Gordan and Jurinovi\'{c}, Luka and Tambi\'{c} Andra\v{s}evi\'{c}, Arjana}, year = {2022}, pages = {13}, DOI = {10.3390/ microorganisms10071410}, chapter = {1410}, keywords = {Campylobacter jejuni, antimicrobial resistance, antimicrobial susceptibility testing, bioinformatics, whole genome sequencing, Campylobacter jejuni in primary sterile samples}, journal = {Microorganisms}, doi = {10.3390/ microorganisms10071410}, volume = {10}, number = {7}, issn = {2076-2607}, title = {Resistome Analysis of Campylobacter jejuni Strains Isolated from Human Stool and Primary Sterile Samples in Croatia}, keyword = {Campylobacter jejuni, antimicrobial resistance, antimicrobial susceptibility testing, bioinformatics, whole genome sequencing, Campylobacter jejuni in primary sterile samples}, chapternumber = {1410} }
@article{article, author = {\v{S}oprek, Silvija and Duvnjak, Sanja and Kompes, Gordan and Jurinovi\'{c}, Luka and Tambi\'{c} Andra\v{s}evi\'{c}, Arjana}, year = {2022}, pages = {13}, DOI = {10.3390/ microorganisms10071410}, chapter = {1410}, keywords = {Campylobacter jejuni, antimicrobial resistance, antimicrobial susceptibility testing, bioinformatics, whole genome sequencing, Campylobacter jejuni in primary sterile samples}, journal = {Microorganisms}, doi = {10.3390/ microorganisms10071410}, volume = {10}, number = {7}, issn = {2076-2607}, title = {Resistome Analysis of Campylobacter jejuni Strains Isolated from Human Stool and Primary Sterile Samples in Croatia}, keyword = {Campylobacter jejuni, antimicrobial resistance, antimicrobial susceptibility testing, bioinformatics, whole genome sequencing, Campylobacter jejuni in primary sterile samples}, chapternumber = {1410} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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