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Pregled bibliografske jedinice broj: 1205179

Biological evaluation of novel bicyclic heteroaromatic benzazole derived acrylonitriles: synthesis, antiproliferative and antibacterial activity


Perin, Nataša; Cindrić, Maja; Zlatar, Ivo; Persoons, Leentje; Daelemans, Dirk; Radovanović, Vedrana; Banjanac, Mihailo; Brajša, Karmen; Hranjec, Marijana
Biological evaluation of novel bicyclic heteroaromatic benzazole derived acrylonitriles: synthesis, antiproliferative and antibacterial activity // Medicinal chemistry research, 31 (2022), 8; 1339-1350 doi:10.1007/s00044-022-02915-w (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1205179 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Biological evaluation of novel bicyclic heteroaromatic benzazole derived acrylonitriles: synthesis, antiproliferative and antibacterial activity

Autori
Perin, Nataša ; Cindrić, Maja ; Zlatar, Ivo ; Persoons, Leentje ; Daelemans, Dirk ; Radovanović, Vedrana ; Banjanac, Mihailo ; Brajša, Karmen ; Hranjec, Marijana

Izvornik
Medicinal chemistry research (1054-2523) 31 (2022), 8; 1339-1350

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acrylonitriles ; antibacterial activity ; antiproliferative activity in vitro ; benzimidazoles ; benzothiazoles ; imidazo[4, 5-b]pyridines

Sažetak
Within this manuscript we present the design, synthesis and biological evaluation of novel benzazole derived acrylonitriles bearing bicyclic heteroaromatic rings. Either benzimidazole, benzothiazole or imidazo[4, 5-b]pyridine scaffolds are linked via acrylonitrile linker with different bicyclic heteroaromatics. All newly prepared are evaluated for their in vitro antiproliferative activity on 8 human cancer cells as well as on three human lung cancer cell lines in MTS citotoxicity and in BrdU proliferative assays performed on 2D and 3D assay format. Majority of tested compounds showed weak activity with the exception of naphthyl substituted benzimidazole derivative 13 and benzothiazolyl substituted derivative 17, both benzimidazole derived acrylonitriles. Also, as a promising compounds have proven to be imidazo[4, 5-b]pyridine derivatives 25 and 30 with selective activity against A549 cells. Furthermore, all compounds were tested for their antibacterial activity against nine bacteria strains and Saccharomyces cerevisiae. Only benzo[b]furan-2-yl substituted benzimidazole derivative 14 showed moderate activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-4379 - Istraživanje antioksidativnog djelovanja benzazolskog skeleta u dizajnu novih antitumorskih agensa (AntioxPot) (Hranjec, Marijana, HRZZ - 2018-01) ( CroRIS)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Fidelta d.o.o.

Poveznice na cjeloviti tekst rada:

doi link.springer.com dx.doi.org

Citiraj ovu publikaciju:

Perin, Nataša; Cindrić, Maja; Zlatar, Ivo; Persoons, Leentje; Daelemans, Dirk; Radovanović, Vedrana; Banjanac, Mihailo; Brajša, Karmen; Hranjec, Marijana
Biological evaluation of novel bicyclic heteroaromatic benzazole derived acrylonitriles: synthesis, antiproliferative and antibacterial activity // Medicinal chemistry research, 31 (2022), 8; 1339-1350 doi:10.1007/s00044-022-02915-w (međunarodna recenzija, članak, znanstveni)
Perin, N., Cindrić, M., Zlatar, I., Persoons, L., Daelemans, D., Radovanović, V., Banjanac, M., Brajša, K. & Hranjec, M. (2022) Biological evaluation of novel bicyclic heteroaromatic benzazole derived acrylonitriles: synthesis, antiproliferative and antibacterial activity. Medicinal chemistry research, 31 (8), 1339-1350 doi:10.1007/s00044-022-02915-w.
@article{article, author = {Perin, Nata\v{s}a and Cindri\'{c}, Maja and Zlatar, Ivo and Persoons, Leentje and Daelemans, Dirk and Radovanovi\'{c}, Vedrana and Banjanac, Mihailo and Braj\v{s}a, Karmen and Hranjec, Marijana}, year = {2022}, pages = {1339-1350}, DOI = {10.1007/s00044-022-02915-w}, keywords = {acrylonitriles, antibacterial activity, antiproliferative activity in vitro, benzimidazoles, benzothiazoles, imidazo[4, 5-b]pyridines}, journal = {Medicinal chemistry research}, doi = {10.1007/s00044-022-02915-w}, volume = {31}, number = {8}, issn = {1054-2523}, title = {Biological evaluation of novel bicyclic heteroaromatic benzazole derived acrylonitriles: synthesis, antiproliferative and antibacterial activity}, keyword = {acrylonitriles, antibacterial activity, antiproliferative activity in vitro, benzimidazoles, benzothiazoles, imidazo[4, 5-b]pyridines} }
@article{article, author = {Perin, Nata\v{s}a and Cindri\'{c}, Maja and Zlatar, Ivo and Persoons, Leentje and Daelemans, Dirk and Radovanovi\'{c}, Vedrana and Banjanac, Mihailo and Braj\v{s}a, Karmen and Hranjec, Marijana}, year = {2022}, pages = {1339-1350}, DOI = {10.1007/s00044-022-02915-w}, keywords = {acrylonitriles, antibacterial activity, antiproliferative activity in vitro, benzimidazoles, benzothiazoles, imidazo[4, 5-b]pyridines}, journal = {Medicinal chemistry research}, doi = {10.1007/s00044-022-02915-w}, volume = {31}, number = {8}, issn = {1054-2523}, title = {Biological evaluation of novel bicyclic heteroaromatic benzazole derived acrylonitriles: synthesis, antiproliferative and antibacterial activity}, keyword = {acrylonitriles, antibacterial activity, antiproliferative activity in vitro, benzimidazoles, benzothiazoles, imidazo[4, 5-b]pyridines} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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  • CA Search (Chemical Abstracts)


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