Naslov
COVID-19 convalescent plasma as long-term therapy in immunodeficient patients?

Autori
Rnjak, Dina ; Ravlić, Sanda ; Šola, Ana-Marija ; Halassy, Beata ; Šemnički , Joško ; Šuperba , Martina ; Hećimović , Ana ; Kurolt , Ivan- Christian ; Kurtović , Tihana ; Mačak Šafranko , Željka ; Zenić , Lucija ; Polančec , Denis ; Bendelja , Krešo ; Mušlin , Tatjana ; Jukić , Irena ; Vuk , Tomislav ; Artuković , Marinko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
2021 Annual Meeting of Croatian Immunological Society

Mjesto i datum
Trogir, Hrvatska, 23.09.2021. - 25.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
passive antibody therapy ; convalescent plasma ; COVID-19 ; SARS-CoV-2 ; wild-type virus neutralization assay

Sažetak
The patients with hematological malignancies are a vulnerable group to COVID-19, due to the immunodeficiency resulting from the underlying disease and oncological treatment that significantly impair cellular and humoral immunity. Here we report on a beneficial impact of a passive immunotherapy with convalescent plasma to treat a prolonged, active COVID-19 in a patient with a history of nasopharyngeal diffuse large B- cell lymphoma treated with the therapy inducing substantial impairment of particularly humoral arm of immune system. The specific aim was to quantify SARS-CoV-2 neutralizing antibodies in a patient plasma during the course of therapy. Besides the standard of care treatment and monitoring, neutralizing antibody titers in patient's serum samples, calibrated according to the First WHO International Standard for anti-SARS-CoV-2 immunoglobulin (human), were quantified in a time- dependent manner. During the immunotherapy period peripheral blood flow cytometry immunophenotyping was conducted to characterize lymphocyte subpopulations. The phases of clinical improvements and worsening coincided with transfused neutralizing antibodies rises and drops in the patient's systemic circulation, proving their contribution in controlling the disease progress. Therapeutic approach based on convalescent plasma transfusion transformed a prolonged, active COVID-19 into a partly manageable chronic disease.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA