Pregled bibliografske jedinice broj: 1204463
Key Factors for Thymic Function and Development
Key Factors for Thymic Function and Development // Frontiers in Immunology, 13 (2022), 926516, 18 doi:10.3389/fimmu.2022.926516 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 1204463 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Key Factors for Thymic Function and Development
Autori
Shichkin, Valentin P. ; Antica, Mariastefania
Izvornik
Frontiers in Immunology (1664-3224) 13
(2022);
926516, 18
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
thymus ; thymic epithelial cells (TEC) ; thymic microenvironment, thymus regeneration, T cells ; intrathymic regulators ; thymic stem cells
Sažetak
The thymus is the organ responsible for T cell development and the formation of the adaptive immunity function. Its multicellular environment consists mainly of the different stromal cells and maturing T lymphocytes. Thymus-specific progenitors of epithelial, mesenchymal, and lymphoid cells with stem cell properties represent only minor populations. The thymic stromal structure predominantly determines the function of the thymus. The stromal components, mostly epithelial and mesenchymal cells, form this specialized area. They support the consistent developmental program of functionally distinct conventional T cell subpopulations. These include the MHC restricted single positive CD4+ CD8- and CD4- CD8+ cells, regulatory T lymphocytes (Foxp3+), innate natural killer T cells (iNKT), and γδT cells. Several physiological causes comprising stress and aging and medical treatments such as thymectomy and chemo/radiotherapy can harm the thymus function. The present review summarizes our knowledge of the development and function of the thymus with a focus on thymic epithelial cells as well as other stromal components and the signaling and transcriptional pathways underlying the thymic cell interaction. These critical thymus components are significant for T cell differentiation and restoring the thymic function after damage to reach the therapeutic benefits.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-IP-2020-02-2431 - Obnova timusa za preciznu medicinu u liječenju tumora i leukemija (THYMINNOVA) (Antica, Mariastefania, HRZZ - 2020-02) ( CroRIS)
--KK.01.1.1.01.0008 - Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platormi i potencijala (CERRM) (Ježek, Davor; Vukičević, Slobodan) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Mariastefania Antica
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE