Naslov
Pro/Post-Biotics as Biomodulators of the Intestinal Microbiome

Autori
Novak, Jasna ; Leboš Pavunc, Andreja ; Banić, Martina ; Butorac, Katarina ; Čuljak, Nina ; Šušković, Jagoda ; Kos, Blaženka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts from “7th Croatian Congress of Microbiology with International Participation“ / Sviličić Petrić, Ines ; Leboš Pavunc, Andreja ; Šantić, Marina ; Kifer, Domagoj - Zagreb : Recedo digital, 2022, 31-31

ISBN
978-953-7778-18-7

Skup
7th Croatian Congress of Microbiology

Mjesto i datum
Sveti Martin na Muri, Hrvatska, 24.05.2022. - 27.05.2022

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
intestinal microbiota ; biomodulators ; S-layer proteins ; exopolysaccharides ; bacteriocins

Sažetak
The awareness of the importance of the intestinal microbiota for host health has spurred efforts to develop strategies for its modulation during functional dysbiosis. Namely, the disruptions of the intestinal microbiome are linked not only with gastrointestinal but also extraintestinal disorders. Growing evidence suggests that intestinal microbiota biomodulators may again establish normal intestinal microbiome composition. Biomodulators, in addition to the almost conventional use of probiotics and prebiotics, also include new therapies proposed as the application of postbiotics, next-generation probiotics, and even faecal microbiota transplantation of a healthy donor. Though probiotic strains have been extensively investigated, the mechanistic basis of their health-promoting effects remains unclear. It is the surface-exposed or secreted cellular compounds that are the key molecules that interface bacteria to their environment while providing various functions. Therefore, the aim here is to present specific probiotic strains expressing trigger molecules that show the potential to act as postbiotics. In particular, case-studies related to the structural and/or functional characterization of S-layer proteins and exopolysaccharides released in the microenvironment will be presented. In addition, enzyme activities encompassed within the proteolytic system responsible for the accumulation of biopeptides in casein-rich sources will be discussed. Finally, the aim is to comment on the challenges in discovering the specific biomolecules, bacteriocins as another potential postbiotic. At first, the approaches in the screening and identification of novel lactic acid bacteria as probiotics and their target trigger biomolecules will be shown as well as evaluation of their importance in cell-to-cell or cell-to- host interactions. This implies their biological role in the functional properties of probiotic strains, specifically protective roles after exposure to stress conditions, immunomodulatory activity, antimicrobial activity, and adhesion. A metagenomics approach was applied to assess the capacity of probiotics to modulate the intestinal microbiome composition in vivo. Expanding knowledge on probiotics and trigger molecules thereof will induce further research related to both the improvement of bioprocess and new applications of probiotics as promising living drugs.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

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