Pregled bibliografske jedinice broj: 1202151
Anion-Sensing Properties of Cyclopentaphenylalanine
Anion-Sensing Properties of Cyclopentaphenylalanine // Molecules, 27 (2022), 12; 3918, 16 doi:10.3390/molecules27123918 (međunarodna recenzija, članak, znanstveni)
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Naslov
Anion-Sensing Properties of Cyclopentaphenylalanine
Autori
Petters, Ivan ; Modrušan, Matija ; Vidović, Nikolina ; Crnolatac, Ivo ; Cindro, Nikola ; Piantanida, Ivo ; Speranza, Giovanna ; Horvat, Gordan ; Tomišić, Vladislav
Izvornik
Molecules (1420-3049) 27
(2022), 12;
3918, 16
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Cyclopeptides ; Anion binding ; Fluorimetry ; NMR spectroscopy ; Circular Dichroism ; Molecular dynamics
Sažetak
Cyclic pentaphenylalanine was studied as an efficient anion sensor for halides, thiocyanate and oxoanions in acetonitrile and methanol. Stability constants of the corresponding complexes were determined by means of fluorimetric, spectrophotometric, 1 H NMR, and microcalorimetric titrations. A detailed structural overview of receptor–anion complexes was obtained by classical molecular dynamics (MD) simulations. The results of 1 H NMR and MD studies indicated that the bound anions were coordinated by the amide groups of cyclopeptide, as expected. Circular dichroism (CD) titrations were also carried out in acetonitrile. To the best of our knowledge, this is the first example of the detection of anion binding by cyclopeptide using CD spectroscopy. The CD spectra were calculated from the structures obtained by MD simulations and were qualitatively in agreement with the experimental data. The stoichiometry of almost all complexes was 1:1 (receptor:anion), except for dihydrogen phosphate where the binding of dihydrogen phosphate dimer was observed in acetonitrile. The affinity of the cyclopeptide receptor was correlated with the structure of anion coordination sphere, as well as with the solvation properties of the examined solvents.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2019-04-9560 - Koordinacijske reakcije makrocikličkih liganada u otopini (MacroSol) (Tomišić, Vladislav, HRZZ - 2019-04) ( CroRIS)
HRZZ-IP-2018-01-5475 - Višekromoforne probe za prepoznavanje pojedinih struktura DNA, RNA i proteina (BioMultiChromoProbes) (Piantanida, Ivo, HRZZ - 2018-01) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Institut za poljoprivredu i turizam, Poreč
Profili:
Nikola Cindro
(autor)
Gordan Horvat
(autor)
Matija Modrušan
(autor)
Vladislav Tomišić
(autor)
Ivo Piantanida
(autor)
Ivo Crnolatac
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE