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Pregled bibliografske jedinice broj: 1200890

RhBMP6 in autologous blood coagulum with ceramics induces rapid spinal fusion in sheep

Štoković, Nikola; Ivanjko, Natalia; Pećin, Marko; Smajlovic, Ana; Ivkić, Niko; Capak, Hrvoje; Vrbanac, Zoran; Vnuk, Drazen; Matičić, Drazen; Vukicevic, Slobodan
RhBMP6 in autologous blood coagulum with ceramics induces rapid spinal fusion in sheep // Bone Reports, 16 (2022), xx-xx doi:.org/10.1016/j.bonr.2022.101326 (međunarodna recenzija, ostalo, znanstveni)

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Naslov
RhBMP6 in autologous blood coagulum with ceramics induces rapid spinal fusion in sheep

Autori
Štoković, Nikola ; Ivanjko, Natalia ; Pećin, Marko ; Smajlovic, Ana ; Ivkić, Niko ; Capak, Hrvoje ; Vrbanac, Zoran ; Vnuk, Drazen ; Matičić, Drazen ; Vukicevic, Slobodan

Izvornik
Bone Reports (2352-1872) 16 (2022); Xx-xx

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, ostalo, znanstveni

Ključne riječi
rhBMP6 ; ceramics ; spinal fusion ; rapid ; sheep

Sažetak
Introduction: Osteogrow, an autologous bone graft substitute (ABGS) containing recombinant human Bone Morphogenetic Protein 6 (rhBMP6) within autologous blood coagulum (ABC) as a BMP carrier is a novel therapeutic solution for bone regeneration. Calcium phosphate ceramic particles might be added to Osteogrow to improve the biomechanical properties of implants. Purpose: This study aimed to evaluate Osteogrow with synthetic ceramic particles (Osteogrow C) in the sheep posterolateral spinal fusion (PLF) model. Methods: Osteogrow C implants containing 74-420 μm (n=6) or 500- 1700 μm (n=6) ceramic particles were prepared as follow: lyophilized rhBMP6 (0, 5 mg per implant) was dissolved in water and added to 8 mL of autologous blood withdrawn from the jugular vein and mixed with ceramic particles. Osteoinductive implants were placed between L4-L5 transverse processes of sheep (Ovis Aries, Merinolaandschaf breed, aged 4-5 years). Spinal fusion was assessed 9 weeks after surgery by in vivo CT scanning. Animals were terminated 14 weeks following implantation to further evaluate the spinal fusion outcome by microCT, biomechanical testing, and histology. The study was approved by the Institutional and National Ethics Committees Results: Osteogrow C implants with both 74-420 and 500-1700 μm ceramic particles induced formation of bone and fusion with transverse processes 9 weeks following implantation as evidenced by in vivo CT scans. Ex vivo microCT, histological and biomechanical analyses confirmed these findings and revealed that newly formed bone was completely integrated with native transverse processes providing biomechanically competent fusion. Conclusions: Osteogrow C implants induce rapid spinal fusion in the sheep PLF model and provide a possible therapeutic solution for patients with degenerative disease of the spine.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Veterinarska medicina



POVEZANOST RADA

Projekti:
--KK.01.1.1.01.0008 - Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platormi i potencijala (CERRM) (Ježek, Davor; Vukičević, Slobodan) ( CroRIS)

Ustanove:
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb

Profili:

Avatar Url Nikola Štoković (autor)

Avatar Url Natalia Ivanjko (autor)

Avatar Url Dražen Matičić (autor)

Avatar Url Marko Pećin (autor)

Avatar Url Dražen Vnuk (autor)

Avatar Url Niko Ivkić (autor)

Avatar Url Slobodan Vukičević (autor)

Avatar Url Hrvoje Capak (autor)

Avatar Url Zoran Vrbanac (autor)

Avatar Url Ana Smajlović (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Štoković, Nikola; Ivanjko, Natalia; Pećin, Marko; Smajlovic, Ana; Ivkić, Niko; Capak, Hrvoje; Vrbanac, Zoran; Vnuk, Drazen; Matičić, Drazen; Vukicevic, Slobodan
RhBMP6 in autologous blood coagulum with ceramics induces rapid spinal fusion in sheep // Bone Reports, 16 (2022), xx-xx doi:.org/10.1016/j.bonr.2022.101326 (međunarodna recenzija, ostalo, znanstveni)
Štoković, N., Ivanjko, N., Pećin, M., Smajlovic, A., Ivkić, N., Capak, H., Vrbanac, Z., Vnuk, D., Matičić, D. & Vukicevic, S. (2022) RhBMP6 in autologous blood coagulum with ceramics induces rapid spinal fusion in sheep. Bone Reports, 16, xx-xx doi:.org/10.1016/j.bonr.2022.101326.
@article{article, author = {\v{S}tokovi\'{c}, Nikola and Ivanjko, Natalia and Pe\'{c}in, Marko and Smajlovic, Ana and Ivki\'{c}, Niko and Capak, Hrvoje and Vrbanac, Zoran and Vnuk, Drazen and Mati\v{c}i\'{c}, Drazen and Vukicevic, Slobodan}, year = {2022}, pages = {xx-xx}, DOI = {doi.org/10.1016/j.bonr.2022.101326}, keywords = {rhBMP6, ceramics, spinal fusion, rapid, sheep}, journal = {Bone Reports}, doi = {doi.org/10.1016/j.bonr.2022.101326}, volume = {16}, issn = {2352-1872}, title = {RhBMP6 in autologous blood coagulum with ceramics induces rapid spinal fusion in sheep}, keyword = {rhBMP6, ceramics, spinal fusion, rapid, sheep} }
@article{article, author = {\v{S}tokovi\'{c}, Nikola and Ivanjko, Natalia and Pe\'{c}in, Marko and Smajlovic, Ana and Ivki\'{c}, Niko and Capak, Hrvoje and Vrbanac, Zoran and Vnuk, Drazen and Mati\v{c}i\'{c}, Drazen and Vukicevic, Slobodan}, year = {2022}, pages = {xx-xx}, DOI = {doi.org/10.1016/j.bonr.2022.101326}, keywords = {rhBMP6, ceramics, spinal fusion, rapid, sheep}, journal = {Bone Reports}, doi = {doi.org/10.1016/j.bonr.2022.101326}, volume = {16}, issn = {2352-1872}, title = {RhBMP6 in autologous blood coagulum with ceramics induces rapid spinal fusion in sheep}, keyword = {rhBMP6, ceramics, spinal fusion, rapid, sheep} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Emerging Sources Citation Index (ESCI)
  • Scopus
  • MEDLINE

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