Naslov
The Patho‐Neurophysiological Basis and Treatment of Focal Laryngeal Dystonia: A Narrative Review and Two Case Reports Applying TMS over the Laryngeal Motor Cortex

Autori
Rogić Vidaković, Maja ; Gunjača, Ivana ; Bukić, Josipa ; Košta, Vana ; Šoda, Joško ; Konstantinović, Ivan ; Bošković, Braco ; Bilić, Irena ; Režić Mužinić, Nikolina

Izvornik
Journal of clinical medicine (2077-0383) 11 (2022), 12; 3453, 22

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
spasmodic dysphonia ; laryngeal dystonia ; dystonia ; focal dystonia ; focal laryngeal dystonia

Sažetak
Focal laryngeal dystonia (LD) is a rare, idiopathic disease affecting the laryngeal musculature with an unknown cause and clinically presented as adductor LD or rarely as abductor LD. The most effective treatment options include the injection of botulinum toxin (BoNT) into the affected laryngeal muscle. The aim of this narrative review is to summarize the patho‐neuro‐ physiological and genetic background of LD, as well as the standard recommended therapy (BoNT) and pharmacological treatment options, and to discuss possible treatment perspectives using neuro‐modulation techniques such as repetitive transcranial magnetic stimulation (rTMS) and vibrotactile stimulation. The review will present two LD cases, patients with adductor and abductor LD, standard diagnostic procedure, treatments and achievement, and the results of cortical excitability mapping the primary motor cortex for the representation of the laryngeal muscles in the assessment of corticospinal and corticobulbar excitability.

Izvorni jezik
Engleski

Znanstvena područja
Elektrotehnika, Kliničke medicinske znanosti, Farmacija, Logopedija

POVEZANOST RADA