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Pregled bibliografske jedinice broj: 1199808

Activation of 5-HT1A receptors in the preBötzinger region has little impact on the respiratory pattern

Radocaj, Tomislav; Mustapic, Sanda; Prkic, Ivana; Stucke, Astrid G.; Hopp, Francis A.; Stuth, Eckehard A.E.; Zuperku, Edward J.
Activation of 5-HT1A receptors in the preBötzinger region has little impact on the respiratory pattern // Respiratory Physiology & ; Neurobiology, 212-214 (2015), 9-19 doi:10.1016/j.resp.2015.03.005 (međunarodna recenzija, članak, znanstveni)

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Naslov
Activation of 5-HT1A receptors in the preBötzinger region has little impact on the respiratory pattern

Autori
Radocaj, Tomislav ; Mustapic, Sanda ; Prkic, Ivana ; Stucke, Astrid G. ; Hopp, Francis A. ; Stuth, Eckehard A.E. ; Zuperku, Edward J.

Izvornik
Respiratory Physiology & ; Neurobiology (1569-9048) 212-214 (2015); 9-19

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5-HT receptors ; 5-HT(1A) receptors ; 8-OH-DPAT ; Control of breathing ; Respiratory neurons ; preBötzinger complex.

Sažetak
The preBötzinger (preBötC) complex has been suggested as the primary site where systemically administered selective serotonin agonists have been shown to reduce or prevent opioid-induced depression of breathing. However, this hypothesis has not been tested pharmacologically in vivo. This study sought to determine whether 5-HT1A receptors within the preBötC and ventral respiratory column (VRC) mediate the tachypneic response induced by intravenous (IV) (±)-8- Hydroxy-2-diproplyaminotetralin hydrobromide (8- OH-DPAT) in a decerebrated dog model. IV 8-OH-DPAT (19 ± 2 μg/kg) reduced both inspiratory (I) and expiratory (E) durations by ∼ 40%, but had no effect on peak phrenic activity (PPA). Picoejection of 1, 10, and 100 μM 8-OH-DPAT on I and E preBötC neurons produced dose-dependent decreases up to ∼ 40% in peak discharge. Surprisingly, microinjections of 8-OH-DPAT and 5- HT within the VRC from the obex to 9 mm rostral had no effect on timing and PPA. These results suggest that the tachypneic effects of IV 8-OH- DPAT are due to receptors located outside of the areas we studied.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Profili:

Avatar Url Tomislav Radočaj (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Radocaj, Tomislav; Mustapic, Sanda; Prkic, Ivana; Stucke, Astrid G.; Hopp, Francis A.; Stuth, Eckehard A.E.; Zuperku, Edward J.
Activation of 5-HT1A receptors in the preBötzinger region has little impact on the respiratory pattern // Respiratory Physiology & ; Neurobiology, 212-214 (2015), 9-19 doi:10.1016/j.resp.2015.03.005 (međunarodna recenzija, članak, znanstveni)
Radocaj, T., Mustapic, S., Prkic, I., Stucke, A., Hopp, F., Stuth, E. & Zuperku, E. (2015) Activation of 5-HT1A receptors in the preBötzinger region has little impact on the respiratory pattern. Respiratory Physiology & ; Neurobiology, 212-214, 9-19 doi:10.1016/j.resp.2015.03.005.
@article{article, author = {Radocaj, Tomislav and Mustapic, Sanda and Prkic, Ivana and Stucke, Astrid G. and Hopp, Francis A. and Stuth, Eckehard A.E. and Zuperku, Edward J.}, year = {2015}, pages = {9-19}, DOI = {10.1016/j.resp.2015.03.005}, keywords = {5-HT receptors, 5-HT(1A) receptors, 8-OH-DPAT, Control of breathing, Respiratory neurons, preB\"{o}tzinger complex.}, journal = {Respiratory Physiology and ; Neurobiology}, doi = {10.1016/j.resp.2015.03.005}, volume = {212-214}, issn = {1569-9048}, title = {Activation of 5-HT1A receptors in the preB\"{o}tzinger region has little impact on the respiratory pattern}, keyword = {5-HT receptors, 5-HT(1A) receptors, 8-OH-DPAT, Control of breathing, Respiratory neurons, preB\"{o}tzinger complex.} }
@article{article, author = {Radocaj, Tomislav and Mustapic, Sanda and Prkic, Ivana and Stucke, Astrid G. and Hopp, Francis A. and Stuth, Eckehard A.E. and Zuperku, Edward J.}, year = {2015}, pages = {9-19}, DOI = {10.1016/j.resp.2015.03.005}, keywords = {5-HT receptors, 5-HT(1A) receptors, 8-OH-DPAT, Control of breathing, Respiratory neurons, preB\"{o}tzinger complex.}, journal = {Respiratory Physiology and ; Neurobiology}, doi = {10.1016/j.resp.2015.03.005}, volume = {212-214}, issn = {1569-9048}, title = {Activation of 5-HT1A receptors in the preB\"{o}tzinger region has little impact on the respiratory pattern}, keyword = {5-HT receptors, 5-HT(1A) receptors, 8-OH-DPAT, Control of breathing, Respiratory neurons, preB\"{o}tzinger complex.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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