Naslov
Assessment of the corticobulbar excitability in laryngeal dystonia/spasmodic dysphonia-Preliminary results and reviw of current knowledge on neuromodulation treatments

Autori
Rogić Vidaković ; Maja ; Đogaš, Zoran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
5 th European Conference of Brain Stimulation in Psychiatry- TMS in Clinical Practice- What Works and What Fails?

Mjesto i datum
Zagreb, Hrvatska, 02.04.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
dystonia ; laryngeal dystonia ; spasmodic dysphonia ; adductor laryngeal dystonia ; abductor laryngeal dystonia ; rTMS ; TMS ; tDCS

Sažetak
Laryngeal dystonia (LD) is a form of dystonia, a group of movement disorders that vary in their symptoms, causes, progression, and treatments. LD is a rare neurological disorder with an unknown cause affecting the intrinsic muscles of the larynx with a prevalence of 14-35 per 100, 000. Vocal symptoms range from sporadic difficulty to sustained inability to phonate, with vocal tremors (voice breaks) or strained or choked speech. In severe cases, an affected subject may barely speak. LD can potentially significantly impact the quality of life, and the disorder can cause psychiatric disturbances, including depression and anxiety.The diagnosis is challenging due to a lack of pathophysiological biomarkers and involves multidisciplinary experts (neurologist, psychiatrist, speech and language pathologist, otorhinolaryngologist, neurosurgeon). The most effective treatment options include the injection of botulinum toxin (BoNT) into the affected laryngeal muscle, but the BoNT injection often leads to adverse events and does not represent the total cure of the LD due to the need for repeated injections. The study objective is to: (1) provide current knowledge on the neurophysiological basis of LD by TMS examination of motor evoked potentials from laryngeal muscles and cortical silent period as a measure of intracortical inhibition in primary motor cortices, (2) present two LD cases, abductor and adductor LD type of LS and the use of TMS in the assessment of corticobulbar excitability. The study will discuss possible treatment perspectives using neuro- modulation techniques such as rTMS, tDCS, and vibrotactile stimulation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
The abstract is expected to be published in the
journal Psychiatria Danubina. Upon publication, it
will be posted on CROSBI.

POVEZANOST RADA