Naslov
Tracing epithelial–mesenchymal transition in intracranial meningioma

Autori
Bukovac, Anja ; Cesarec-Augustinović, Sanja ; Kafka, Anja ; Müller, Danko ; Orešković, Darko ; Raguž, Marina ; Pećina-Šlaus, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Program and abstracts / - , 2022, 42-42

Skup
11th Brain Tumor Meeting 2022

Mjesto i datum
Berlin, Njemačka, 19.05.2022. - 20.05.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
epithelial to mesenchymal transition ; intracranial meningioma ; cadherin switch

Sažetak
Epithelial to mesenchymal transition (EMT) is a leading process associated with invasive character of different cancer types and formation of metastasis. The cause of progression and expression of malignant character in a small group of meningioma is still unclear. To investigate the role of EMT in intracranial meningioma progression, main actors of cadherin switch, E- and N-cadherin, as well as EMT transcription factors TWIST1, SNAIL and SLUG, were studied. Analyzes of different meningioma grades revealed that genetic changes in CDH1 gene (E-cadherin) were usually accompanied with expression in relation to E-cadherin was shown. Reported low levels of expression or silencing of E-cadherin could be a result of strong TWIST1, SNAIL and SLUG expression. The increase in the TWIST1 expression was accompanied by an increase of the SNAIL and SLUG expression (p = 0.033). Strong expression of SNAIL and SLUG, especially when located in nuclei, was significantly associated with higher meningioma grades (p = 0.001). Still, meningiomas without CDH1 genetic changes were significantly more likely to lack nuclear SNAIL and SLUG expression or it was observed in less than 50% of nuclei, in contrast to samples with CDH1 gene changes (p = 0.000). Our results suggest the role of aberrant EMT in meningioma progression, emphasizing SNAIL and SLUG nuclear expression as potential prognostic marker.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

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