Pregled bibliografske jedinice broj: 1198440
Three different methods confirmed the association of macro and microelements with cerebrospinal fluid biomarkers of Alzheimer's disease
Three different methods confirmed the association of macro and microelements with cerebrospinal fluid biomarkers of Alzheimer's disease // 8th Mediterranean Neuroscience Conference : the proceedings, Xjenza, vol. 10, special issue / Sebu, Cristiana (ur.).
Msida: Malta Chamber of Scientists, 2022. str. 142-142 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1198440 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Three different methods confirmed the association of macro and microelements with cerebrospinal fluid biomarkers of Alzheimer's disease
Autori
Mihelčić, Matej ; Babić Leko, Mirjana ; Jurasović, Jasna ; Nikolac Perković, Matea ; Španić, Ena ; Sekovanić, Ankica ; Orct, Tatjana ; Zubčić, Klara ; Langer Horvat, Lea ; Pleić, Nikolina ; Kiđemet-Piskač, Spomenka ; Vogrinc, Željka ; Pivac, Nela ; Borovečki, Fran ; Hof, Patrick R. ; Šimić, Goran
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
8th Mediterranean Neuroscience Conference : the proceedings, Xjenza, vol. 10, special issue
/ Sebu, Cristiana - Msida : Malta Chamber of Scientists, 2022, 142-142
Skup
8th Mediterranean Neuroscience Society Conference (MNS)
Mjesto i datum
Dubrovnik, Hrvatska, 29.05.2022. - 02.06.2022
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Alzheimer's disease ; cerebrospinal fluid protein biomarkers ; cognitive impairment ; inductively coupled plasma mass spectroscopy ; machine learning ; metalloids ; metals ; plasma ; principal component analysis ; redescription mining ; trace elements
Sažetak
The homeostasis of metals is altered in the brain of Alzheimer’s disease (AD) patients. It was proposed that changes in metal homeostasis are related to AD pathology. Additionally, metals that are not present in the brain under normal circumstances (such as mercury, lead and cadmium) were associated with AD pathogenesis. The aim of this study was to test if macro and microelements (Li, B, Na, Mg, Al, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Tl, Pb, and Hg) measured in cerebrospinal fluid (CSF) and plasma of patients with dementia are associated with CSF biomarkers of AD. CSF AD biomarkers reflect pathological changes in AD brain, while the involvement of different metals in AD pathogenesis is still the matter of debate. Macro and microelements were determined by inductively coupled plasma mass spectroscopy (ICP-MS), while CSF biomarkers were measured by enzyme-linked immunosorbent assays (ELISA). Macro and microelements were measured in CSF of 194 subjects and in plasma of 144 subjects (study included overall 125 AD patients, 50 patients with mild cognitive disorder and 19 healthy controls). We used three different statistical methods to test the association of macro and microelements with CSF biomarkers of AD. All three methods (simple correlation and two machine learning algorithms ; redescription mining and principal component analysis [PCA]) demonstrated the association of macro and microelements with CSF biomarkers of AD. Possible explanations for association of macro and microelements with CSF biomarkers of AD await elucidation of their environmental sources or detection of their release from brain tissue due to cell death. Also, these results should be further validated on larger cohorts.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)
POVEZANOST RADA
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Opća bolnica Varaždin,
Klinički bolnički centar Zagreb,
Medicinski fakultet, Split
Profili:
Nikolina Pleić
(autor)
Željka Vogrinc
(autor)
Matea Nikolac Perković
(autor)
Matej Mihelčić
(autor)
Ankica Sekovanić
(autor)
Spomenka Kiđemet-Piskač
(autor)
Klara Zubčić
(autor)
Mirjana Babić Leko
(autor)
Fran Borovečki
(autor)
Nela Pivac
(autor)
Tatjana Orct
(autor)
Goran Šimić
(autor)
Jasna Jurasović
(autor)
Ena Španić
(autor)
Lea Langer Horvat
(autor)