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Pregled bibliografske jedinice broj: 1198425

Polymorphisms within serotonin receptor genes are associated with genetic, cerebrospinal fluid and neuropsychological biomarkers of Alzheimer’s disease

Babić Leko, Mirjana; Nikolac Perković, Matea; Španić, Ena; Švob Štrac, Dubravka; Pleić, Nikolina; Vogrinc, Željka; Gunjača, Ivana; Klepac, Nataša; Borovečki, Fran; Pivac, Nela et al.
Polymorphisms within serotonin receptor genes are associated with genetic, cerebrospinal fluid and neuropsychological biomarkers of Alzheimer’s disease // Xjenza, vol. 10, special issue / Sebu, Cristiana (ur.).
Msida: Malta Chamber of Scientists, 2022. str. 141-141 (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 1198425 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Polymorphisms within serotonin receptor genes are associated with genetic, cerebrospinal fluid and neuropsychological biomarkers of Alzheimer’s disease

Autori
Babić Leko, Mirjana ; Nikolac Perković, Matea ; Španić, Ena ; Švob Štrac, Dubravka ; Pleić, Nikolina ; Vogrinc, Željka ; Gunjača, Ivana ; Klepac, Nataša ; Borovečki, Fran ; Pivac, Nela ; Zemunik, Tatijana ; Hof, Patrick R. ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Xjenza, vol. 10, special issue / Sebu, Cristiana - Msida : Malta Chamber of Scientists, 2022, 141-141

Skup
8th Mediterranean Neuroscience Society Conference (MNS)

Mjesto i datum
Dubrovnik, Hrvatska, 29.05.2022. - 02.06.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Alzheimer's disease ; APOE genotype ; behavioral and psychological symptoms of dementia ; cerebrospinal fluid biomarkers ; cognitive impairment ; neuropsychological testing ; polymorphisms ; receptors ; serotonin

Sažetak
Decrease in serotonergic transmission throughout the brain is among the earliest pathological changes in Alzheimer’s disease (AD). Serotonergic receptors are also affected in AD. Polymorphisms in genes for serotonin (5HT) receptors were mostly associated with behavioral and psychological symptoms of dementia (BPSD). In this study we aimed to test if individuals carrying different genotypes in 5HTR1B rs13212041, 5HTR2A rs6313 (T102C), 5HTR2C rs3813929 (-795C/T) and 5HTR6 rs1805054 (C267T) polymorphisms have higher risk for development of AD. Study included 115 AD patients and 53 mild cognitive impairment patients with determined cerebrospinal fluid (CSF) AD biomarkers, neuropsychological tests, and apolipoprotein E (APOE) haplotype and 2701 cognitively healthy individuals with determined APOE haplotype. All four analysed polymorphisms of serotonin receptor genes showed the association with either genetic, CSF or neuropsychological biomarkers of AD. Thus, these polymorphisms deserve further investigation as potential genetic biomarkers and therapeutic targets for AD.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Medicinski fakultet, Split

Profili:

Avatar Url Fran Borovečki (autor)

Avatar Url Nela Pivac (autor)

Avatar Url Nataša Klepac (autor)

Avatar Url Ena Španić (autor)

Avatar Url Ivana Gunjača (autor)

Avatar Url Tatijana Zemunik (autor)

Avatar Url Goran Šimić (autor)

Avatar Url Nikolina Pleić (autor)

Avatar Url Željka Vogrinc (autor)

Avatar Url Dubravka Švob Štrac (autor)

Avatar Url Matea Nikolac Perković (autor)

Avatar Url Mirjana Babić Leko (autor)

Citiraj ovu publikaciju:

Babić Leko, Mirjana; Nikolac Perković, Matea; Španić, Ena; Švob Štrac, Dubravka; Pleić, Nikolina; Vogrinc, Željka; Gunjača, Ivana; Klepac, Nataša; Borovečki, Fran; Pivac, Nela et al.
Polymorphisms within serotonin receptor genes are associated with genetic, cerebrospinal fluid and neuropsychological biomarkers of Alzheimer’s disease // Xjenza, vol. 10, special issue / Sebu, Cristiana (ur.).
Msida: Malta Chamber of Scientists, 2022. str. 141-141 (poster, međunarodna recenzija, sažetak, znanstveni)
Babić Leko, M., Nikolac Perković, M., Španić, E., Švob Štrac, D., Pleić, N., Vogrinc, Ž., Gunjača, I., Klepac, N., Borovečki, F. & Pivac, N. (2022) Polymorphisms within serotonin receptor genes are associated with genetic, cerebrospinal fluid and neuropsychological biomarkers of Alzheimer’s disease. U: Sebu, C. (ur.)Xjenza, vol. 10, special issue.
@article{article, author = {Babi\'{c} Leko, Mirjana and Nikolac Perkovi\'{c}, Matea and \v{S}pani\'{c}, Ena and \v{S}vob \v{S}trac, Dubravka and Plei\'{c}, Nikolina and Vogrinc, \v{Z}eljka and Gunja\v{c}a, Ivana and Klepac, Nata\v{s}a and Borove\v{c}ki, Fran and Pivac, Nela and Zemunik, Tatijana and Hof, Patrick R. and \v{S}imi\'{c}, Goran}, editor = {Sebu, C.}, year = {2022}, pages = {141-141}, keywords = {Alzheimer's disease, APOE genotype, behavioral and psychological symptoms of dementia, cerebrospinal fluid biomarkers, cognitive impairment, neuropsychological testing, polymorphisms, receptors, serotonin}, title = {Polymorphisms within serotonin receptor genes are associated with genetic, cerebrospinal fluid and neuropsychological biomarkers of Alzheimer’s disease}, keyword = {Alzheimer's disease, APOE genotype, behavioral and psychological symptoms of dementia, cerebrospinal fluid biomarkers, cognitive impairment, neuropsychological testing, polymorphisms, receptors, serotonin}, publisher = {Malta Chamber of Scientists}, publisherplace = {Dubrovnik, Hrvatska} }
@article{article, author = {Babi\'{c} Leko, Mirjana and Nikolac Perkovi\'{c}, Matea and \v{S}pani\'{c}, Ena and \v{S}vob \v{S}trac, Dubravka and Plei\'{c}, Nikolina and Vogrinc, \v{Z}eljka and Gunja\v{c}a, Ivana and Klepac, Nata\v{s}a and Borove\v{c}ki, Fran and Pivac, Nela and Zemunik, Tatijana and Hof, Patrick R. and \v{S}imi\'{c}, Goran}, editor = {Sebu, C.}, year = {2022}, pages = {141-141}, keywords = {Alzheimer's disease, APOE genotype, behavioral and psychological symptoms of dementia, cerebrospinal fluid biomarkers, cognitive impairment, neuropsychological testing, polymorphisms, receptors, serotonin}, title = {Polymorphisms within serotonin receptor genes are associated with genetic, cerebrospinal fluid and neuropsychological biomarkers of Alzheimer’s disease}, keyword = {Alzheimer's disease, APOE genotype, behavioral and psychological symptoms of dementia, cerebrospinal fluid biomarkers, cognitive impairment, neuropsychological testing, polymorphisms, receptors, serotonin}, publisher = {Malta Chamber of Scientists}, publisherplace = {Dubrovnik, Hrvatska} }

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