Naslov
Patch testing with a new composition of the Mercapto mix - a multicenter study from the international contact dermatitis research group

Autori
Isaksson, Marléne ; Andersen, Klaus E ; Cannavó, Alicia ; Elsner, Peter ; Goh, Chee-Leok ; Gonçalo, Margarida ; Goossens, An ; Ljubojević Hadžavdić, Suzana ; Pratt, Melanie ; Puangpet, Pailin ; Sasseville, Denis ; Verma , Kaushal ; Bruze, Magnus

Izvornik
Dermatitis (1710-3568) 32 (2021), 3; 160-163

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
patch testing ; new composition of the Mercapto mix ; multicenter study

Sažetak
Background: Mercaptobenzothiazole compounds are associated with allergic contact dermatitis caused by rubber products. Several screening substances have been used for patch testing. Objective: To compare the frequency of positive test reactions to a mercapto mix containing a higher concentration of 2-mercaptobenzothiazole with reactions to the combination of 2- mercaptobenzothiazole 2.0% and mercapto mix 2.0%. Methods: There were 7103 dermatitis patients in 12 International Contact Dermatitis Research Group dermatology departments who were patch tested with 2-mercaptobenzothiazole 2.0% petrolatum (pet.), mercapto mix 2.0% pet., and mercapto mix 3.5% pet. Results: Contact allergy to the 3 test preparations varied among the 12 centers: 2- mercaptobenzothiazole 2.0% pet. (0-2.4%), mercapto mix 2.0% pet. (0-4.9%), and mercapto mix 3.5% pet. (0-1.4%). 2-Mercaptobenzothiazole 2.0% and mercapto mix 2.0% detected a few more positive patients compared with mercapto mix 3.5%, but the difference was statistically insignificant (mercapto mix 2.0% pet., P = 1.0 ; 2-mercapto- benzothiazole 2.0% pet., P = 0.66). Conclusions: Mercapto mix 3.5% pet. is not better than 2- mercaptobenzothiazole 2.0% and mercapto mix 2.0% by a difference that is significant. By using only 1 test preparation (mercapto mix 3.5%), an additional hapten could be tested. No cases of suspected/proven patch test sensitization were registered.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA