Naslov
Cytogenetic status of interventional radiology unit workers occupationally exposed to low-dose ionising radiation: A pilot study

Autori
Gerić, Marko ; Popić, Jelena ; Gajski, Goran ; Garaj-Vrhovac, Vera

Izvornik
Mutation Research/Genetic Toxicology and Environmental Mutagenesis (1383-5718) 843 (2019); 46-51

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Comet assay ; Cytokinesis-block micronucleus assay ; Dosimetry ; Human biomonitoring ; Interventional radiologists

Sažetak
Interventional radiology unit workers represent one of the occupationally most exposed populations to low-dose ionizing radiation. Since there are many uncertainties in research of doses below 100 mSv, this study attempted to evaluate DNA damage levels in chronically exposed personnel. The study group consisted of 24 subjects matched with a control population by the number of participants, age, gender ratio, active smoking status, the period of blood sampling, and residence. Based on regular dosimetry using thermoluminiscent dosimeters, our study group occupationally received a dose of 1.82 ± 3.60 mSv over the last year. The results of the cytokinesis-block micronucleus assay and the comet assay showed a higher nuclear buds frequency (4.09 ± 1.88) and tail length (15.46 ± 1.47 μm) than in the control group (2.96 ± 1.67, 14.05 ± 1.36 μm, respectively). Differences in other descriptors from both tests did not reach statistical significance. Further investigations are needed to develop algorithms for improving personal dosimetry and those that would engage larger biomonitoring study groups.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

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