Naslov
High sensitivity X-ray phase contrast imaging by laboratory grating-based interferometry at high Talbot order geometry

Autori
Vila-Comamala, Joan ; Romano, Lucia ; Jefimovs, Konstantins ; Dejea, Hector ; Bonnin, Ann ; Cook, Andrew C. ; Planinc, Ivo ; Čikes, Maja ; Wang, Zhentian ; Stampanoni, Marco

Izvornik
Optics express (1094-4087) 29 (2021), 2; 2049-2064

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
tomography ; microtomography

Sažetak
X-ray phase contrast imaging is a powerful analysis technique for materials science and biomedicine. Here, we report on laboratory grating-based X-ray interferometry employing a microfocus X-ray source and a high Talbot order (35th) asymmetric geometry to achieve high angular sensitivity and high spatial resolution X-ray phase contrast imaging in a compact system (total length <1 m). The detection of very small refractive angles (∼50 nrad) at an interferometer design energy of 19 keV was enabled by combining small period X-ray gratings (1.0, 1.5 and 3.0 µm) and a single-photon counting X-ray detector (75 µm pixel size). The performance of the X-ray interferometer was fully characterized in terms of angular sensitivity and spatial resolution. Finally, the potential of laboratory X-ray phase contrast for biomedical imaging is demonstrated by obtaining high resolution X-ray phase tomographies of a mouse embryo embedded in solid paraffin and a formalin-fixed full-thickness sample of human left ventricle in water with a spatial resolution of 21.5 µm.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA