Naslov
Liver Graft Failure and Bile Cast Nephropathy

Autori
Mrzljak, Anna ; Jureković, Željka ; Novak, Rafaela ; Maksimović, Bojana ; Mikulić, Danko ; Galešić Ljubanović, Danica

Izvornik
The Korean Journal of Gastroenterology (1598-9992) 75 (2020), 3; 167-171

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Acute kidney injury ; Cholestasis ; Hyperbilirubinemia ; Liver failure ; Liver transplantation

Sažetak
The consequences of graft failure after liver transplantation (LT) range far beyond the liver. The kidneys are often affected, where persistent and progressive cholestasis can result in acute kidney injury (AKI) leading to the development of bile cast nephropathy (BCN). BCN is an often unrecognized condition that is characterized by proximal tubulopathy and the formation of bile casts in the distal tubules, which is almost diagnosed exclusively on a kidney biopsy or autopsy. This condition is potentially reversible, provided the bilirubin levels can be reduced early. LT may represent a treatment option in the case of irreversible liver (or liver graft) failure, which is beneficial for both the liver and the kidney. This paper reports a case of BCN in a patient with idiopathic graft failure after LT. Despite his chronic kidney disease, liver re- transplantation led to the successful improvement of his AKI.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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