Pregled bibliografske jedinice broj: 1196711
Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD
Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD // Biomolecules, 12 (2022), 5; 736, 18 doi:10.3390/biom12050736 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1196711 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Reduced Platelet MAO-B Activity Is Associated with
Psychotic, Positive, and Depressive Symptoms in PTSD
Autori
Repovečki, Senka ; Nedić Erjavec, Gordana ; Uzun, Suzana ; Tudor, Lucija ; Nikolac Perković, Matea ; Konjevod, Marcela ; Kozumplik, Oliver ; Švob Štrac, Dubravka ; Kovačić Petrović, Zrnka ; Mimica, Ninoslav ; Pivac, Nela
Izvornik
Biomolecules (2218-273X) 12
(2022), 5;
736, 18
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
PTSD ; platelet MAO‐B activity ; clinical symptoms ; PANSS ; CAPS
Sažetak
Post‐traumatic stress disorder (PTSD) is a trauma‐ related disorder. Platelet monoamine oxidase (MAO‐ B) is a peripheral biomarker associated with various symptoms in different psychopathologies, but its role in PTSD or different symptoms in PTSD is not clear. This study elucidated the association between platelet MAO‐B activity and clinical symptoms occurring in PTSD. Platelet MAO‐ B activity was determined in 1053 male Caucasian subjects: 559 war veterans with PTSD (DSM‐5 criteria), 62 combat exposed veterans who did not develop PTSD, and 432 non‐combat exposed healthy controls. Clinical symptoms in PTSD were determined using CAPS and PANSS. Platelet MAO‐B activity, controlled for the effect of smoking, was significantly increased in PTSD with severe versus mild and moderate traumatic symptoms, and was significantly decreased in PTSD subjects with severe versus mild positive, psychotic, and depressive symptoms. This finding was further confirmed with reduced platelet MAO‐B activity in PTSD veterans with severe versus mild individual items of the PANSS‐depressed, PANSS‐psychotic, and PANSS‐positive subscales. Altered platelet MAO‐B activity, controlled for the possible confounders, was associated with the development and severity of different symptoms occurring in PTSD. These findings confirmed the role of platelet MAO‐B activity as a peripheral marker of various psychopathological symptoms.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Sveučilište u Zagrebu
Profili:
Nela Pivac
(autor)
Senka Repovečki
(autor)
Oliver Kozumplik
(autor)
Marcela Konjevod
(autor)
Suzana Uzun
(autor)
Dubravka Švob Štrac
(autor)
Matea Nikolac Perković
(autor)
Lucija Tudor
(autor)
Zrnka Kovačić Petrović
(autor)
Ninoslav Mimica
(autor)
Gordana Nedić Erjavec
(autor)
Poveznice na cjeloviti tekst rada:
Pristup cjelovitom tekstu rada doi www.mdpi.com doi.org fulir.irb.hrCitiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE